Efficient synthesis of (S)-N-Boc-3-hydroxypiperidine using an (R)-specific carbonyl reductase from Candida parapsilosis

Chen, JJ; Yan, M; Xu, L

Yan, M (reprint author), Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, 30 Puzhu Rd, Nanjing 211816, Jiangsu, Peoples R China.

WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2017; 33 (3):

Abstract

(S)-N-Boc-3-hydroxypiperidine (S-NBHP) is a critical chiral intermediate in the synthesis of pharmaceuticals, including ibrutinib, the active pharmace......

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