All-trans retinoic acid works synergistically with the γ-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T cells

García-Guerrero, E; Rodríguez-Lobato, LG; Sierro-Martínez, B; Danhof, S; Bates, S; Frenz, S; Härtle, L; Götz, R; Sauer, M; Rasche, L; Kortüm, KM; Pérez-Simón, JA; Einsele, H; Hudecek, M; Prommersberger, SR

Prommersberger, SR (通讯作者)，Univ Klinikum Wurzburg, Lehrstuhl Zellulare Immuntherapie, Med Klin & Poliklin 2, Wurzburg, Germany.;Prommersberger, SR (通讯作者)，Univ Klinikum Wurzburg, Med Klin & Poliklin 2, Wurzburg, Germany.

HAEMATOLOGICA, 2023; 108 (2): 568

Abstract

B-cell maturation antigen (BCMA) is the lead antigen for chimeric antigen receptor (CAR) T-cell therapy in multiple myeloma (MM). A challenge is inter......

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