Membrane anchoring of the DIRAS3 N-terminal extension permits tumor suppressor function

Liang, XW; Jung, SY; Fong, LW; Bildik, G; Gray, JP; Mao, WQ; Zhang, SX; Millward, SW; Gorfe, AA; Zhou, Y; Lu, Z; Bast , RC Jr

Lu, Z; Bast , RC Jr (通讯作者)，Univ Texas MD Anderson Canc Ctr Houston, Dept Expt Therapeut, Houston, TX 77054 USA.

ISCIENCE, 2023; 26 (11):

Abstract

DIRAS3 is an imprinted tumor suppressor gene encoding a GTPase that has a distinctive N-terminal extension (NTE) not found in other RAS proteins. This......

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