Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2

Serafim, RAM; Gama, FHD; Dutra, LA; dos Reis, CV; Vasconcelos, SNS; Santiago, AD; Takarada, JE; Di Pillo, F; Azevedo, H; Mascarello, A; Elkins, JM; Massirer, KB; Gileadi, O; Guimaraes, CRW; Counago, RM

Counago, RM (reprint author), Univ Estadual Campinas, UNICAMP, CBMEG, Ctr Quim Med CQMED, BR-13083875 Campinas, SP, Brazil.; Counago, RM (reprint author), Univ Estadual Campinas, Inst Biol, Dept Genet & Evolucao, Struct Genom Consortium, BR-13083886 Campi

ACS MEDICINAL CHEMISTRY LETTERS, 2019; 10 (9): 1266

Abstract

Vaccinia-related kinases 1 and 2 (VRK1 and VRK2) are human Ser/Thr protein kinases associated with increased cell division and neurological disorders.......

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