Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins

Malm, M; Kuo, CC; Barzadd, MM; Mebrahtu, A; Wistbacka, N; Razavi, R; Volk, AL; Lundqvist, M; Kotol, D; Tegel, H; Hober, S; Edfors, F; Graslund, T; Chotteau, V; Field, R; Varley, PG; Roth, RG; Lewis, NE; Hatton, D; Rockberg, J

Lewis, NE (通讯作者)，Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA.;Lewis, NE (通讯作者)，Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA.;Rockberg, J (通讯作者)，KTH Royal Inst Technol, Sch Engn Sci Chem Biotechnol & Hlth, S-510691 Stockholm, Sweden.

METABOLIC ENGINEERING, 2022; 72 (): 171

Abstract

Biologics represent the fastest growing group of therapeutics, but many advanced recombinant protein moieties remain difficult to produce. Here, we id......

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