Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition

Kong, N; Tao, W; Ling, X; Wang, JQ; Xiao, YL; Shi, SJ; Ji, XY; Shajii, A; Gan, ST; Kim, NY; Duda, DG; Xie, T; Farokhzad, OC; Shi, JJ

Tao, W; Farokhzad, OC; Shi, JJ (reprint author), Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA.; Tao, W; Farokhzad, OC; Shi, JJ (reprint author), Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA.;

SCIENCE TRANSLATIONAL MEDICINE, 2019; 11 (523):

Abstract

Loss of function in tumor suppressor genes is commonly associated with the onset/progression of cancer and treatment resistance. The p53 tumor suppres......

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