Bibenzyl analogue DS-1 inhibits MDM2-mediated p53 degradation and sensitizes apoptosis in lung cancer cells

Putri, HE; Nutho, B; Rungrotmongkol, T; Sritularak, B; Vinayanuwattikun, C; Chanvorachote, P

Chanvorachote, P (corresponding author), Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Pharmacol & Physiol, Bangkok 10330, Thailand.; Chanvorachote, P (corresponding author), Chulalongkorn Univ, Fac Pharmaceut Sci, Cell Based Drug & Hlth Prod Dev Res Unit, Bangkok 10330, Thailand.

PHYTOMEDICINE, 2021; 85 ():

Abstract

Background: Lung cancer is a leading fatal malignancy due to the high incidence of treatment failure. Dysfunction of the tumor suppressor p53 contribu......

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