BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non-Small Cell Lung Cancer

Adeegbe, DO; Liu, SW; Hattersley, MM; Bowden, M; Zhou, CSW; Li, S; Vlahos, R; Grondine, M; Dolgalev, I; Ivanova, EV; Quinn, MM; Gao, P; Hammerman, PS; Bradner, JE; Diehl, JA; Rustgi, AK; Bass, AJ; Tsirigos, A; Freeman, GJ; Chen, HW; Wong, KK

Wong, KK (reprint author), NYU, Langone Med Ctr, 550 1St Ave, New York, NY 10016 USA.

CANCER IMMUNOLOGY RESEARCH, 2018; 6 (10): 1234

Abstract

KRAS mutation is present in approximately 30% of human lung adenocarcinomas. Although recent advances in targeted therapy have shown great promise, ef......

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