Lapatinib as a Dual Tyrosine Kinase Inhibitor Unexpectedly Activates Akt in MDA-MB-231 Triple-Negative Breast Cancer Cells

Kaboli, PJ; Ling, KH

Kaboli, PJ (corresponding author), Southwest Med Univ, Dept Pharmacol, Sch Pharm, Luzhou 646000, Sichuan, Peoples R China.

LETTERS IN DRUG DESIGN & DISCOVERY, 2020; 17 (8): 1060

Abstract

Background: MDA-MB-231 is a Triple-Negative Breast Cancer (TNBC) cell line, which is resistant to tyrosine kinase inhibitors, such as lapatinib. Lapat......

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