Potent Neutralization of SARS-CoV-2 by Hetero-Bivalent Alpaca Nanobodies Targeting the Spike Receptor-Binding Domain

Ma, H; Zeng, WH; Meng, XZ; Huang, XX; Yang, YR; Zhao, D; Zhou, PG; Wang, XF; Zhao, CC; Sun, Y; Wang, PH; Ou, HC; Hu, XW; Xiang, Y; Jin, TCA

Jin, TCA (corresponding author), Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Pulm & Crit Care Med, Div Life Sci & Med, Hefei, Anhui, Peoples R China.; Jin, TCA (corresponding author), Univ Sci & Technol China, Div Life Sci & Med, Hefei Natl Lab Phys Sci Microscale, Lab Struct Immunol,CAS Key Lab Innate Immun & Chr, Hefei, Anhui, Peoples R China.; Xiang, Y (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol Immunol & Mol Genet, San Antonio, TX 78229 USA.; Jin, T

JOURNAL OF VIROLOGY, 2021; 95 (10):

Abstract

Cellular entry of SARS-CoV-2 requires the binding between the receptor-binding domain (RBD) of the viral Spike protein and the cellular angiotensin-co......

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