Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways

Khuanjing, T; Maneechote, C; Ongnok, B; Prathumsap, N; Arinno, A; Chunchai, T; Arunsak, B; Chattipakorn, SC; Chattipakorn, N

Chattipakorn, N (通讯作者)，Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai 50200, Thailand.;Chattipakorn, N (通讯作者)，Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai 50200, Thailand.;Chattipakorn, N (通讯作者)，Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.

MOLECULAR MEDICINE, 2023; 29 (1):

Abstract

BackgroundTrastuzumab (Trz)-induced cardiotoxicity (TIC) is one of the most common adverse effects of targeted anticancer agents. Although oxidative s......

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