Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease

Mehta, RS; Mayers, JR; Zhang, YC; Bhosle, A; Glasser, NR; Nguyen, LH; Ma, WJ; Bae, S; Branck, T; Song, KJ; Sebastian, L; Pacheco, JA; Seo, HS; Clish, C; Dhe-Paganon, S; Ananthakrishnan, AN; Franzosa, EA; Balskus, EP; Chan, AT; Huttenhower, C

Huttenhower, C (通讯作者)，MIT Harvard, Broad Inst, Cambridge, MA 02142 USA.;Huttenhower, C (通讯作者)，Harvard Univ, T H Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.;Huttenhower, C (通讯作者)，Harvard Univ, Harvard Chan Microbiome Publ Hlth Ctr, T H Chan Sch Publ Hlth, Boston, MA 02115 USA.;Huttenhower, C (通讯作者)，Harvard Univ, Howard Hughes Med Inst, Dept Immunol & Infect Dis, Boston, MA 02115 USA.

NATURE MEDICINE, 2023; 29 (3): 700

Abstract

For decades, variability in clinical efficacy of the widely used inflammatory bowel disease (IBD) drug 5-aminosalicylic acid (5-ASA) has been attribut......

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