Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30

Qin, X; Wang, R; Xu, HK; Tu, LC; Chen, HL; Li, H; Liu, N; Wang, JP; Li, SM; Yin, F; Xu, NH; Li, ZG

Li, ZG (通讯作者)，Peking Univ, Sch Chem Biol & Biotechnol, State Key Lab Chem Oncogen, Shenzhen Grad Sch, Shenzhen, Peoples R China.;Yin, F (通讯作者)，Pingshan Translat Med Ctr, Shenzhen Bay Lab, Shenzhen, Peoples R China.;Xu, NH (通讯作者)，Tsinghua Univ, Tsinghua Shenzhen Int Grad Sch, Inst Biopharmaceut & Hlth Engn, Shenzhen, Peoples R China.

AUTOPHAGY, 2022; 18 (9): 2178

Abstract

The mitochondrial-anchored deubiquitinating enzyme USP30 (ubiquitin specific peptidase 30) antagonizes PRKN/parkin-mediated mitophagy, making it a pot......

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