A Non-immunogenic Bivalent D-Protein Potently Inhibits Retinal Vascularization and Tumor Growth

Marinec, PS; Landgraf, KE; Uppalapati, M; Chen, G; Xie, D; Jiang, QY; Zhao, YL; Petriello, A; Deshayes, K; Kent, SBH; Ault-Riche, D; Sidhu, SS

Ault-Riche, D; Sidhu, SS (corresponding author), Reflex Pharmaceut, Incline Village, NV 89451 USA.; Sidhu, SS (corresponding author), Univ Toronto, Donnelly Ctr, Dept Mol Genet, Toronto, ON M5S 3E1, Canada.

ACS CHEMICAL BIOLOGY, 2021; 16 (3): 548

Abstract

We report a general approach to engineering multivalent D-proteins with antibody-like activities in vivo. Mirror-image phage display and structure-gui......

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