ApoE4 activates C/EBP beta/delta-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease

Wang, ZH; Xia, YY; Liu, P; Liu, X; Edgington-Mitchell, L; Lei, KC; Yu, SP; Wang, XC; Ye, KQ

Ye, KQ (corresponding author), Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA.; Wang, XC (corresponding author), Huazhong Univ Sci & Technol, Dept Pathophysiol, Tongji Med Coll, Key Lab,Minist Educ Neurol Dis, Wuhan, Peoples R China.

PROGRESS IN NEUROBIOLOGY, 2021; 202 ():

Abstract

ApoE4, an apolipoprotein implicated in cholesterol transport and amyloid-beta (A beta) metabolism, is a major genetic risk determinant for Alzheimer's......

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