Reconstituted spray-dried phenytoin-loaded nanocapsules improve the in vivo phenytoin anticonvulsant effect and the survival time in mice

de Oliveira, EG; Cardoso, AM; Paese, K; Coradini, K; de Oliveira, CV; Pohlmann, AR; Oliveira, MS; Guterres, SS; Beck, RCR

Beck, RCR (reprint author), Univ Fed Rio Grande do Sul, Dept Prod & Controle Med, Ave Ipiranga 2952, BR-90610000 Porto Alegre, RS, Brazil.

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2018; 551 (1-2): 121

Abstract

This study evaluated the in vivo anticonvulsant effect of a spray-dried powder for reconstitution containing phenytoin-loaded lipid-core nanocapsules.......

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