Shear stress-induced cellular senescence blunts liver regeneration through Notch-sirtuin 1-P21/P16 axis

Duan, JL; Ruan, B; Song, P; Fang, ZQ; Yue, ZS; Liu, JJ; Dou, GR; Han, H; Wang, L

Wang, L (通讯作者)，Fourth Mil Med Univ, Xi Jing Hosp, Dept Hepatobiliary Surg, Chang Le Xi St 169, Xian 710032, Peoples R China.;Dou, GR (通讯作者)，Fourth Mil Med Univ, Xi Jing Hosp, Dept Ophthalmol, Chang Le Xi St 169, Xian 710032, Peoples R China.;Han, H (通讯作者)，Fourth Mil Med Univ, Dept Biochem & Mol Biol, Chang Le Xi St 169, Xian 710032, Peoples R China.

HEPATOLOGY, 2022; 75 (3): 584

Abstract

Background and Aims The mechanisms involved in liver regeneration after partial hepatectomy (pHx) are complicated. Cellular senescence, once linked to......

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