Investigation of an artificial solution degradant of linagliptin: An undesired linagliptin urea derivative generates in sample preparation of linagliptin tablet treated by sonication in acetonitrile containing diluent

Lin, JS; Chen, FF; Bao, CH; Ma, J; Li, D; Zheng, LW; Zhu, WQ; Chen, WB; Liu, XM

Lin, JS (通讯作者)，Zhejiang Huahai Pharmaceut Co Ltd, Ctr Excellence Modern Analyt Technol CEMAT, Linhai 317204, Zhejiang, Peoples R China.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2022; 210 ():

Abstract

During the related substances testing method development for linagliptin tablet, an unknown peak was observed in HPLC chromatograms with a level excee......

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