Solution Conformations Shed Light on PROTAC Cell Permeability

Atilaw, Y; Poongavanam, V; Nilsson, CS; Nguyen, D; Giese, A; Meibom, D; Erdelyi, M; Kihlberg, J

Kihlberg, J (corresponding author), Uppsala Univ, Dept Chem BMC, SE-75123 Uppsala, Sweden.

ACS MEDICINAL CHEMISTRY LETTERS, 2021; 12 (1): 107

Abstract

Proteolysis targeting chimeras (PROTACs) induce intracellular degradation of target proteins. Their bifunctional structure puts degraders in a chemica......

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