Asymmetric Hydrogenation of Unfunctionalized Tetrasubstituted Acyclic Olefins

Bigler, R; Mack, KA; Shen, J; Tosatti, P; Han, C; Bachmann, S; Zhang, HM; Scalone, M; Pfaltz, A; Denmark, SE; Hildbrand, S; Gosselin, F

Bigler, R (corresponding author), F Hoffmann La Roche Ltd, Pharmaceut Div, Small Mol Tech Dev, Dept Proc Chem & Catalysis, CH-4070 Basel, Switzerland.; Zhang, HM; Gosselin, F (corresponding author), Genentech Inc, Dept Small Mol Proc Chem, 1 DNA Way, San Francisco, CA 94080 USA.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020; 59 (7): 2844

Abstract

Asymmetric hydrogenation has evolved as one of the most powerful tools to construct stereocenters. However, the asymmetric hydrogenation of unfunction......

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