The landscape of immune dysregulation in Crohn?s disease revealed through single-cell transcriptomic profiling in the ileum and colon

Kong, LJ; Pokatayev, V; Lefkovith, A; Carter, GT; Creasey, EA; Krishna, C; Subramanian, S; Kochar, B; Ashenberg, O; Lau, H; Ananthakrishnan, AN; Graham, DB; Deguine, J; Xavier, RJ

Xavier, RJ (通讯作者),Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Xavier, RJ (通讯作者),Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Boston, MA 02114 USA.;Xavier, RJ (通讯作者),Harvard Med Sch, Boston, MA 02114 USA.;Xavier, RJ (通讯作者),Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA.;Xavier, RJ (通讯作者),Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.;Xavier, RJ (通讯作者),Massachusetts Gen Hosp, Ctr Study Inflammatory Bowel Dis, Boston, MA 02114 USA.

IMMUNITY, 2023; 56 (2): 444

Abstract

Crohn's disease (CD) is a chronic gastrointestinal disease that is increasing in prevalence worldwide. CD is multifactorial, involving the complex int......

Full Text Link