SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation

Yang, X; Wang, Z; Li, X; Liu, BY; Liu, MH; Liu, L; Chen, SY; Ren, MM; Wang, YK; Yu, M; Wang, B; Zou, JH; Zhu, WG; Yin, YX; Gu, W; Luo, JY

Luo, JY (reprint author), Peking Univ, Dept Med Genet, 38 Xueyuan Rd, Beijing 100191, Peoples R China.

CANCER RESEARCH, 2018; 78 (2): 372

Abstract

The mitochondrial serine hydroxymethyltransferase SHMT2, which catalyzes the rate-limiting step in serine catabolism, drives cancer cell proliferation......

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