Conformational restriction of a type II FMS inhibitor leading to discovery of 5-methyl-N-(2-aryl-1H-benzo[d]imidazo-5-yl)isoxazole-4-carboxamide analogues as selective FLT3 inhibitors

Im, D; Moon, H; Kim, J; Oh, Y; Jang, M; Hah, JM

Hah, JM (reprint author), Hanyang Univ, Coll Pharm, Hanyangdaehakro 55, Ansan 426791, South Korea.; Hah, JM (reprint author), Hanyang Univ, Inst Pharmaceut Sci & Technol, Hanyangdaehakro 55, Ansan 426791, South Korea.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2019; 34 (1): 1716

Abstract

A series of 4-arylamido 5-methylisoxazole derivatives incorporating benzimidazole was designed and synthesised by conformational restriction of an in-......

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