Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice

Nakano, Y; Nakao, S; Sueoka, M; Kasahara, D; Tanno, Y; Sumiyoshi, H; Itoh, T; Miyajima, A; Hozumi, K; Inagaki, Y

Inagaki, Y (通讯作者)，Tokai Univ, Ctr Matrix Biol & Med, Grad Sch Med, Isehara, Kanagawa, Japan.;Inagaki, Y (通讯作者)，Tokai Univ, Dept Innovat Med Sci, Sch Med, Isehara, Kanagawa, Japan.;Inagaki, Y (通讯作者)，Tokai Univ, Inst Med Sci, Isehara, Kanagawa, Japan.

COMMUNICATIONS BIOLOGY, 2022; 5 (1):

Abstract

Dll4/Notch1 signal promotes the progression of HCC, while Jag1/Notch2 signal antagonistically suppresses it in murine chemical hepatocarcinogenesis. N......

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