Diabetes Care:2月大时糖尿病孕妇的宝宝体重开始超标

2016-05-22 MedSci MedSci原创

发表在Diabetes Care的一项研究表明,患有妊娠期糖尿病的产妇分娩的婴儿即便护理良好和采用母乳喂养,即便宝宝们出生时没有脂肪含量的差异,但他们在2-3月大时仍然比正常婴儿胖16%。这项研究首次发现,妊娠期糖尿病女性分娩的婴儿在出生数月内较正常婴儿体重增加更多。这项研究表明婴儿母亲妊娠期糖尿病有更大的脂肪组织在早期阶段,这可能是许多健康问题的先兆。伦敦帝国理工学院的Karen Logan博士

发表在Diabetes Care的一项研究表明,患有妊娠期糖尿病的产妇分娩的婴儿即便护理良好和采用母乳喂养,即便宝宝们出生时没有脂肪含量的差异,但他们在2-3月大时仍然比正常婴儿胖16%。这项研究首次发现,妊娠期糖尿病女性分娩的婴儿在出生数月内较正常婴儿体重增加更多。这项研究表明婴儿母亲妊娠期糖尿病有更大的脂肪组织在早期阶段,这可能是许多健康问题的先兆。

伦敦帝国理工学院的Karen Logan博士指出,这表明妊娠糖尿病产妇分娩的婴儿较正常婴儿有更多的脂肪组织,因此今后可能会出现更多的健康问题。

既往研究表明妊娠期糖尿病与与后代肥胖和超重有关。最近发表的一项研究指出,妊娠糖尿病和(或)怀孕期间体重增加过多会增加后代10年内的肥胖风险,即使婴儿出生时体重正常,在10年内他们的肥胖风险依旧存在且高于常人。

Logan博士指出,这项研究利用MRI直接测量宝宝脂肪组织含量。共有86名2011年10月-2014年10月出生在切尔西和威斯敏斯特医院的婴儿参与研究。实验组宝宝的母亲患有妊娠期糖尿病(42人),对照组为普通宝宝(44人)。当婴儿出生8-12周时研究人员通过MRI对他们进行全身扫描以评估他们全身脂肪组织含量和肝内脂肪含量。

妊娠期糖尿病女性血糖控制良好,妊娠晚期平均糖化血红蛋白水平为5.3%。大多数婴儿采用母乳喂养,时长为8-12个月(实验组:71%,对照组:74%)。

约11天大时,对照组和实验组宝宝的脂肪总量相似(P=0.55)。10周后实验组婴儿的脂肪总量明显高于对照组(P=0.01)。调整新生儿体重后结论依旧成立(16.0%, P =0.002)。两组宝宝肝脏脂肪含量及分布无明显差异。研究人员认为母亲是否患有妊娠期糖尿病与宝宝今后体重变化有明显关系。但他们表示仍需进行更进一步的研究。

原始出处:
Mothers With Gestational Diabetes Have Fatter Babies at 2 Months,Medscape,19,May,2016

Development of Early Adiposity in Infants of Mothers With Gestational Diabetes Mellitus,Karen M. Logan,et al,Diabetes Care. May 12, 2016

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    2016-06-02 沉心多思

    好文章,得多学习了!

    0

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