空腹血糖超过5.3 mmol/L就不正常?解放军总医院研究

2020-08-12 卢芳 中国循环杂志

体检时,血糖在正常范围就安全?

体检时,血糖在正常范围就安全?

 

近期,解放军总医院田慧等进行的研究发现,≥60岁老年人其空腹血糖≥5.3 mmol/L,即为未来发生糖尿病及心脑血管病警戒值。

 

研究显示,随着老年人空腹血糖值的升高,其步入糖尿病前期、发生糖尿病以及发生心脑血管疾病的风险明显增加。

 

其中,当空腹血糖≥5.3 mmol/L时上述风险成倍增加,如发生心脑血管病的风险较<5.3 mmol/L增加了7倍。

 


60岁老年人群不同空腹血糖水平者在至少随访5年后糖尿病前期、糖尿病及心脑血管病的发生率

 

此外,随访结束时,≥5.3 mmol/L人群较<5.3 mmol/L人群死亡风险增加了47%(图2)。

 

 空腹血糖<5.3 mmol/L组与≥5.3 mmol/L组的生存曲线

 

研究者介绍说,2003年美国ADA指南就提出,将诊断糖尿病前期的切点从6.1 mmol/L下降至5.6 mmol/L。不过不同种族具体值有所差异。

 

上海第六人民医院贾伟平等进行的研究提示,将诊断糖尿病前期的下限调整至5.6mmol/L有利于糖尿病的防治。

 

而作者在之前进行的“馒头餐后2小时血糖在糖尿病筛查中的意义”的研究中提示,符合糖尿病前期和糖尿病诊断的空腹血糖最佳切点为5.3 mmol/L和5.6 mmol/L。

 

不过研究者也指出,空腹血糖5.3 mmol/L作为风险阈值是否适合其他老年人抑或中老年人,还需要做更大人群的数据分析。

 

这项回顾性队列研究共纳入1064例年龄≥60岁健康体检者,其中男性980人,平均年龄(71.7±6.4)年,64.2%受试者合并高血压,52.1%合并血脂紊乱,71.7%合并心血管疾病。入组前3年平均空腹血糖为(4.9±0.4)mmol/L,每人至少随访5年。随访期间,共有126人发展为糖尿病,144人发展为糖尿病前期。

 

来源:赵明星, 阚芳芳, 方福生, 等. 老年人空腹血糖5.3mmol/L与发展为糖代谢异常及心脑血管病变发病风险的队列研究. 中华内科杂志, 2016,55(05): 340-344.

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    2020-08-13 1240394fm61暂无昵称

    不同年龄段呢

    0

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    2020-08-12 洋葱花

    引起重视

    0

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    2020-08-12 百木~

    学习了

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