Gastroenterology Report: 术前全肠外营养改善了接受腹部手术的克罗恩病患者的术后结果

2019-05-24 不详 MedSci原创

尽管克罗恩病(CD)的治疗模式剂效果取得了重大进展,但很大一部分患者需要在诊断后5年内进行手术治疗。营养不良是胃肠道手术后不良术后结果的独立危险因素。关于CD患者术前全肠外营养(TPN)价值目前还有争论,因此,本项研究的目的是确定术前TPN在该人群中的作用。

背景
尽管克罗恩病(CD)的治疗模式剂效果取得了重大进展,但很大一部分患者需要在诊断后5年内进行手术治疗。营养不良是肠道手术后不良术后结果的独立危险因素。关于CD患者术前全肠外营养(TPN)价值目前还有争论,因此,本项研究的目的是确定术前TPN在该人群中的作用。

方法
这是一项在三级转诊中心进行的回顾性队列研究。研究人员将接受腹部手术的CD患者纳入本项研究。将接受术前TPN的患者与对照进行比较。主要观察结果是两组间30天感染和非感染性术后并发症的发生率。

结果
在2007年3月至2017年3月期间,共有144名CD患者接受了腹部手术。将55名接受术前TPN的患者与89名对照进行比较。21例(14.6%)患者出现感染性并发症(TPN组为18.2%,非TPN组为12.3%,P = 0.34),23例(15.9%)出现非感染性并发症(TPN组为14.5%,16.9%)在非TPN组中,P = 0.71)。在多变量分析中,控制组间基线疾病严重程度和营养不良的差异,接受术前TPN≥60天的患者发生非感染性并发症的几率显着降低(优势比0.07,95%置信区间:0.01-0.80 ,P =0.03)。过去6个月体重减轻> 10%是术后并发症的重要预测指标。

结论
在一部分营养不良的CD患者中,TPN是安全的,术前TPN≥60天可减少术后非感染性并发症,而不会增加感染性并发症。

原始出处:

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    2019-07-13 许安
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