Psychiatry Res:低血清白蛋白与老年人长期卒中后抑郁症状相关

2015-11-03 phylis 译 MedSci原创

背景:大约有三分之一的卒中幸存者存在卒中后抑郁。非卒中人群中,抑郁症状与低蛋白血症相关。这在卒中幸存者中比较常见,并且与不良预后和死亡率增高相关。卒中相关性低蛋白血症在卒中后抑郁中的作用尚不清楚。研究者旨在探索卒中发生20月后,血清白蛋白和卒中后抑郁的相关性。方法:从“瑞典哥德堡70 +卒中研究”中选取老年瑞典患者(n = 149)进行观察性队列研究,卒中后20个月进行评估。抽取静脉血并应用气相色

背景:大约有三分之一的卒中幸存者存在卒中后抑郁。非卒中人群中,抑郁症状与低蛋白血症相关。这在卒中幸存者中比较常见,并且与不良预后和死亡率增高相关。卒中相关性低蛋白血症在卒中后抑郁中的作用尚不清楚。研究者旨在探索卒中发生20月后,血清白蛋白和卒中后抑郁的相关性。

方法:从“瑞典哥德堡70 +卒中研究”中选取老年瑞典患者(n = 149)进行观察性队列研究,卒中后20个月进行评估。抽取静脉血并应用气相色谱/质谱法分析血清中白蛋白。应用蒙哥马利-艾森贝格抑郁量表(MADRS)评估患者抑郁症状,应用Barthel指数评定功能障碍。

结果:
协方差分析表明,血清白蛋白水平与抑郁症状相关。校正年龄协变量后,多元协方差分析结果显示3天的残疾评分与抑郁症状相关。临床上卒中幸存者不存在血清白蛋白缺乏。

结论:低血清白蛋白似乎与老年人长期卒中后抑郁症状相关。

原文出处:

Pascoe MC, Skoog I, Blomstrand C, Linden T. Albumin and depression in elderly stroke survivors: An observational cohort study. Psychiatry Res. 2015,Oct 22.


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    2016-01-13 Lynee劲飞扬

    给力

    0

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    2015-11-05 珙桐
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