JAMA Oncol:剧烈运动减少癌症幸存者的死亡风险

2018-06-11 小闪 医学论坛网肿瘤

一项新研究表示,强调剧烈锻炼计划可以显着减少儿童癌症幸存者成人后的全因和特定死亡率。 研究人员表示,我们的研究结果与普通人群中的大量数据一致,表明定期锻炼与全因和特定死亡率的显着降低相关。


项新研究表示,强调剧烈锻炼计划可以显着减少儿童癌症幸存者成人后的全因和特定死亡率。

研究人员表示,我们的研究结果与普通人群中的大量数据一致,表明定期锻炼与全因和特定死亡率的显着降低相关。

研究小组发现每周运动15~18个代谢当量(MET)小时,这相当于每周5天每天快速行走约60分钟,获益最佳。除此之外,获益减弱。

该研究表明,每周增加约40分钟的剧烈运动与显著的健康益处相关,其还符合针对癌症幸存者的国家身体活动指南,其中每周150次中等强度运动或每周5次,每次30次分钟。

研究细节

新的结果来自对来自纵向儿童癌症幸存者研究(CCSS)的15,450名参与者的队列分析。该研究小组在中位随访10年后发现运动与全因死亡率之间存在显著的负相关关系(趋势P= 0.02)。研究人员说,这是在调整包括心血管疾病(CVD)在内的慢性健康状况和关键治疗暴露后观察到的。

在15年中,非原发性全因死亡率累计发生率为11.7%(0 MET小时/每周),3~6个MET小时/每周发生率为8.6%,9~12个MET小时/每周发生率为7.4%,而15~21个MET小时/每周的发生率为8.0%(P <0.001)。

在5,689名幸存者中,8年平均增加8个MET小时/每周的剧烈运动与全运动死亡率,与同时保持运动3~6个小时/每周的低水平运动员相比,全身死亡率下降了40%,(比率,0.60; P =0 .001)。

自我报告问卷的数据

对于这项研究,研究人员分析了CCSS参与者在入选之后从两个单独的问卷中自行报告的运动频率的数据。 1970年1月1日~1999年12月31日,所有幸存者均在21岁以前被诊断并在美国和加拿大的27家儿科三级医院接受治疗。

在基线调查问卷中,癌症诊断后的中位数为17.8年,CCSS参与者被问及在过去7天内曾多少次他们已经做过运动或运动20分钟。受访者的中位年龄为25.9岁,男性为52.8%。

问卷调查显示,经常锻炼和剧烈运动的幸存者在癌症诊断上更年轻,更可能是非吸烟者,而CVD和3级和4级慢性病的危险因素较少。

基线调查问卷中位数为9.6年后,参与者在随访调查中重新评估了剧烈的运动倾向。70%的人表示锻炼行为有所改变,40%表示他们的锻炼次数少于上次调查时的锻炼次数,20%表示他们经常锻炼,10%表示他们保持了以前的高水平活力。

研究人员说,维持或增加运动频率的幸存者更可能是不吸烟者,并且不太可能患有任何先前存在的合并症,这与低锻炼者或非运动者相比较。

在基线和随访调查之间的时间内,该队列共有1,063例死亡:120例因原发癌复发或进展而811例因健康相关原因(包括CVD)而死亡。

研究人员表示,鉴于这些措施以及我们在多项结果中发现的一致性,我们认为研究结果与之前的工作一起支持了一项普遍结论,即锻炼为癌症幸存者提供了显著健康益处。

原始出处:

JessicaM. Scott et al. Association of Exercise With Mortality in Adult Survivors ofChildhood Cancer. JAMA Oncol. Published June 3, 2018.

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    2018-06-13 sunfeifeiyang

    学习

    0

  6. 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createdTime=Mon Jun 11 21:02:34 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323351, encodeId=311f32335170, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon Jun 11 20:59:23 CST 2018, time=2018-06-11, status=1, ipAttribution=)]
    2018-06-13 神功盖世

    学习

    0

  7. 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createdTime=Mon Jun 11 21:02:34 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323351, encodeId=311f32335170, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon Jun 11 20:59:23 CST 2018, time=2018-06-11, status=1, ipAttribution=)]
    2018-06-12 186****0580(小山羊)

    学习了谢谢了

    0

  8. 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createdTime=Mon Jun 11 21:02:34 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323351, encodeId=311f32335170, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon Jun 11 20:59:23 CST 2018, time=2018-06-11, status=1, ipAttribution=)]
    2018-06-12 changjiu

    学习一下谢谢

    0

  9. 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createdTime=Mon Jun 11 21:02:34 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323351, encodeId=311f32335170, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon Jun 11 20:59:23 CST 2018, time=2018-06-11, status=1, ipAttribution=)]
    2018-06-11 Jackie Li

    学习

    0

  10. 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    2018-06-11 三生有幸9135

    学习一下谢谢

    0

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