JAHA:美国孕前肥胖的趋势及其与不良妊娠结局的关系

2021-08-26 MedSci原创 MedSci原创

孕前肥胖的患病率和肥胖相关APO的负担有所增加,主要由妊娠相关高血压所致,并且因人种/民族亚组而异。

随着不良妊娠结局(APO)发生率的增加,人群中肥胖症的患病率也在增加。量化孕前肥胖的当代趋势以及与相关APO(早产、低出生体重和妊娠相关高血压)之间的关联,可为优化女性和子代心脏代谢健康的预防策略提供信息支撑。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员使用国家卫生统计中心出生证明数据进行了一项横断面研究,纳入了2013年至2018年间单胎活产的15至44岁的女性,并按种族/族裔(非西班牙裔白人、非西班牙裔黑人、西班牙裔和非西班牙裔亚裔)进行分层。

研究人员量化了孕前肥胖(体重指数≥30.0kg/m2;如果为非西班牙裔亚洲人,体重指数≥27.5kg/m2)的年患病率。然后,研究人员使用多变量Logistic回归(比值比和人群归因分数)估计与正常体重指数(18.5-24.9kg/m2;如果非西班牙裔亚洲人为18.5-22.9kg/m2)相比,肥胖相关的APO。

在20139891名女性中,2013年至2018年期间孕前肥胖的患病率有所增加:非西班牙裔白人(21.6%-24.8%)、非西班牙裔黑人(32.5%-36.2%)、西班牙裔(26.0%-30.5%),和非西班牙裔亚裔(15.3%-18.6%)女性(所有P趋势<0.001)。2013年至2018年与肥胖相关的APO调整后比值比(95%CI)有所增加,到2018年,比值比的范围从非西班牙裔黑人的1.27(1.25-1.29)到非西班牙裔白人女性的1.94(1.92-1.96)。肥胖与妊娠高血压相关性最强,与早产和低出生体重的相关性不一致。肥胖相关APO的人群归因分数在研究期间增加:非西班牙裔白人(10.6%-14.7%)、非西班牙裔黑人(3.7%-6.9%)、西班牙裔(7.0%-10.4%)和非西班牙裔西班牙裔亚洲(7.4%-9.7%)女性(所有P趋势<0.01)。

由此可见,孕前肥胖的患病率和肥胖相关APO的负担有所增加,主要由妊娠相关高血压所致,并且因人种/民族亚组而异。

原始出处:

Michael C. Wang.et al.Trends in Prepregnancy Obesity and Association With Adverse Pregnancy Outcomes in the United States, 2013 to 2018.JAHA.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.020717

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    2023-06-02 ms8000002144676574

    学习了

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    2021-10-01 szhvet
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    2021-08-28 zhaohui6731
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    2021-08-27 与狼共舞

    认真学习

    0

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    2021-08-26 ms5000000518166734

    已读已读已读已读已读已读已读已读已读已读已读已读已读已读。

    0

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