CELL:研究人员揭示人类神经元的独特性

2018-10-19 海北 MedSci原创

神经元的生物物理特征塑造了大脑中的信息处理方式。 皮质神经元在人类中比在其他物种中更大,但至今为止,研究人员尚不清楚它们的大小如何影响突触整合。

神经元的生物物理特征塑造了大脑中的信息处理方式。 皮质神经元在人类中比在其他物种中更大,但至今为止,研究人员尚不清楚它们的大小如何影响突触整合。
最近,来自麻省理工学院的研究人员从人类树突进行直接电记录,并报告在第5层锥体神经元中存在增强的电隔离。与大鼠树突相比,即使存在树突状尖峰,人类的远端树突也对体细胞提供有限的激发。由于树突电生成的募集减少,人类神经细胞体也表现出较少的破裂。 
最后,研究人员发现人类神经元中降低的离子通道密度导致更高的输入电阻,并且这是人类树突的较低耦合的基础。
因此,研究人员得出结论,人类神经元长度的增加改变了它们的输入输出特性,这将影响皮质计算功能。

原始出处:
LouBeaulieu-Laroche et al. Enhanced Dendritic Compartmentalization in Human Cortical Neurons. CELL 2018, DOI: https://doi.org/10.1016/j.cell.2018.08.045

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    2019-06-16 hb2008ye
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    2019-03-19 维他命
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    2018-10-19 kafei

    学习了谢谢

    0

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    2018-10-19 ylzr123

    好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。

    0

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    2018-10-19 天地飞扬

    了解一下,谢谢分享!

    0

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    2018-10-19 183****7028

    学习

    0

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    2018-10-19 明月清辉

    谢谢分享,学习了

    0

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近期的《自然通讯》杂志上,来自波鸿鲁尔大学的Erhan Genc博士研究团队为我们带来了一项令人哭笑不得的研究。研究者利用最新的成像方法检测了志愿者脑内的神经元树突水平,发现那些智商更高的人,虽然往往具有更大的脑体积和更多的神经元,但是在思考的时候活动神经元反而比较少!

Sci Transl Med:阿尔茨海默药物研发阴云再起!科学家发现BACE1抑制剂可能存在严重认知损失副作用

美国西北大学研究者发现,在成年小鼠中敲除β淀粉样蛋白相关的酶BACE1,虽然不会带来神经发育的相关缺陷,但是海马体苔藓纤维束却受到了明显的影响,长度缩短了近30%!