如果长寿的代价是痴呆，你愿意吗

2015-09-24 MedSci MedSci原创

今年9月23日，日本105岁老人宫崎秀吉(Hidekichi Miyazaki)参加京都大师秋季100米跑比赛，42.22秒是其成绩，被吉尼斯世界纪录组织认定为100米跑最年长的参与者。慈善机构英国阿尔茨海默症研究所(Alzheimer's Research UK)发布了其关于阿兹海默症的新的研究得出结论——约1/3的今年出生的人，会在其一生中患有某种形式的痴呆，而且其中女性比

今年9月23日，日本105岁老人宫崎秀吉(Hidekichi Miyazaki)参加京都大师秋季100米跑比赛，42.22秒是其成绩，被吉尼斯世界纪录组织认定为100米跑最年长的参与者。

慈善机构英国阿尔茨海默症研究所(Alzheimer's Research UK)发布了其关于阿兹海默症的新的研究得出结论——约1/3的今年出生的人，会在其一生中患有某种形式的痴呆，而且其中女性比男性多10%。

这份分析是基于两个数据集的组合。一个是英国国家统计局(Office for National Statistics)在2010年开展的近十年出生的儿童的预期寿命的项目，另一个是认知功能和老化研究（the Cognitive Function and Ageing Studies），这是一个正在进行的关于日益老化的老年痴呆症的患病率的研究。据报告指出：2015年出生的婴儿中，将有32%（其中，27%的男孩和37%的女孩）未来会患上痴呆症。

该慈善机构的负责人诺顿博士补充道：“这是一个好消息，每一代人都活得比过去的时间更长，但重要的是要确保人们能在健康的生活中享受这些额外时光。“

痴呆症已取代癌症成为人们最恐惧的疾病。雷丁大学(University of Reading)的阿尔兹海默病专家马克·达拉斯(Mark Dallas)说：“这份报告凸显了与其他改变生活质量的疾病相比，今年出生的婴儿未来患上痴呆症的人数有多让人震惊。可是，现在从事痴呆症研究的人与癌症研究者的比例是1：5。我们必须加大创新研究方面的投资。”

老年痴呆症只是老年疾病中的一种，除此之外还有许多，如心、脑血管病，老年骨质疏松等。尤其是因为现代生活质量水平的提高，人类精神生活与物质生活的极度不对等造成的压力增多，再加上衰老不可避免地造成的机体免疫功能下降、机体退化变性等，这都会造成老年疾病的患病率会更高。尤其是随着现代医学的不断发展,人类的寿命开始延长，但是许多老年疾病我们目前只能做到预防与控制，而不能治愈。

如果长寿的代价是伴随有痴呆等老年疾病，你愿意吗？——不愿意，然并卵。

在现代医学中，许多医生学者都在探讨生命的奥秘，进而希望健康地延长人类的寿命，这才是打开长寿大门而不用代价的重要钥匙。而衰老一直是生命过程中的核心环节，也是影响整个人类社会健康发展的重要问题。为此，中外学者们进行了许多研究来探讨衰老的机制。

2009年，3位美国科学家因“发现端粒和端粒酶是如何保护染色体的”相关研究，获得了诺贝尔生理或医学奖。他们的研究成果揭开了人类衰老和罹患癌症等严重疾病的奥秘，端粒学说也在此后成为了衰老研究中的主流学说之一。

国内也在多年前开展了众多衰老与疾病的相关研究。1993年，现任中科院院士、北京大学衰老研究中心主任的童坦君院士，就承担了国家自然科学基金首个衰老相关重点项目。童院士还率先在我国开展端粒与人类细胞衰老相关性研究，并就细胞衰老关键基因p16进行了深度探索，发现抑制p16表达，可延缓端粒缩短及细胞衰老。

然而在对人体衰老这一问题不断地探索和研究的过程中，科学家们意识到除了端粒和端粒酶外，还有许多因素可以影响衰老。

1.“返老还童因子”：2014年，Science报道了一种名为GDF11的蛋白，文章称它可以使老年小鼠的心脏、大脑、骨骼肌功能更像年轻小鼠。CDF11也因此被称为“返老还童因子”，科学家称其可能在老年痴呆症的治疗上有重大作用。虽然这一成果还有一定的争议，但仍被Science评为当年10大科学突破之一。

2.干细胞衰老机理：今年5月，中科院生物物理所的刘光慧、北京大学汤富酬以及Salk研究所Juan Carlos Izpisua Belmonte等人，在Science杂志上发表了他们在研究成年早衰症过程中，发现的干细胞衰老机理方面的研究成果。他们的研究为在表观遗传水平实现延缓或逆转细胞衰老奠定了理论基础。

3.除了基因、蛋白、细胞等层面外，生活规律和饮食习惯也是被科学家们公认的、影响人体衰老的关键因素。Nature杂志曾在2014年发表文章称，动物实验表明，控制卡路里和蛋白质的摄入量能起到与服用雷帕霉素和二甲双胍相似的效果，并且能够快速地引发细胞反应，增强抗压能力，减少氧化性损伤和炎症反应。

最近一篇发表在Nature上的综述还表明，线粒体蛋白酶在人类健康衰老和疾病中也扮演着重要的角色。

那么，你好奇人为什么会老吗？你想知道更多的关于衰老与疾病的知识吗？

但是随着各领域对于衰老与疾病问题的深入研究，这个问题的答案也变得越来越复杂。

不过上文中提到的童坦君院士、刘光慧研究员，都将出席《2015衰老与疾病研讨会》，童院士将会亲自发表题为《人为啥老？》的精彩演讲报告，和大家一起交流讨论衰老与疾病领域的最新研究进展和趋势。

10月22日-23日，与国内最权威的专家相约上海，不见不散！

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值得学习

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2016-04-22 忠诚向上

值得学习

72 0
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2016-04-22 忠诚向上

值得学习

114 0
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2016-04-22 忠诚向上

值得学习

71 0
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2016-04-22 忠诚向上

值得学习

93 0
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2016-04-22 忠诚向上

值得学习

112 0
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2016-04-22 忠诚向上

值得学习

110 0
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2016-04-22 忠诚向上

值得学习

113 0

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