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Am J Kidney Dis：女性单侧肾脏发育不全与不良妊娠结局相关！

2017-04-17 xing.T MedSci原创

肾脏发育不全妊娠不良结局
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单侧肾发育不全的女性妊娠不良结局风险更高。

关于妊娠期间单个肾脏影响的数据来自活体肾脏捐赠者的研究。近日，肾脏病领域权威杂志Am J Kidney Dis上发表了一篇研究文章，研究人员评估了因一个肾脏发育不全的单肾女性发生不良妊娠结局的风险。

该研究为配对队列研究，参与者使用了从1996年至2015年期间整合的医疗保健系统获取的7079例出生儿童的数据。研究人员确定了肾脏发育不全的女性，并且只纳入首次妊娠和生产单胎的女性。排除糖尿病和肾脏病患者后，200例肾脏发育不全的女性按1:4匹配年龄（2岁内）、种族和高血压病史的双肾妇女。妊娠前肾脏发育不全是根据国际疾病分类第九版（ICD-9）代码来定义的。该研究的主要结局为不良孕产妇结局，包括早产、剖宫产、子痫前期/子痫和住院天数。新生儿不良终点为次要结局，包括低出生体重（＜2500g）和婴儿死亡/转移到急性住院设施中。

肾发育不全的女性平均分娩孕周为37.9±2.1周，与双肾女性的38.6±1.8周相比。相比于双肾女性，肾发育不全的女性早产（比值比为2.88；95%可信区间为1.86-4.45）、剖宫产分娩（比值比为2.11；95%可信区间为1.49-2.99）、重度子痫前期/子痫（比值比为2.41；95%可信区间为1.23-4.72）、住院天数超过3天（比值比为1.81；95%可信区间为1.18-2.78）的风险增加。肾发育不全与婴儿死亡/转移至急性设施（比值比为2.60；95%可信区间为0.57-11.89）或早产后低出生体重（比值比为2.11；95%可信区间为0.76-5.88）的风险增加显著相关。

单侧肾发育不全的女性妊娠不良结局风险更高。


原始出处：

Jessica Kendrick,et al. Association of Unilateral Renal Agenesis With Adverse Outcomes in Pregnancy: A Matched Cohort Study. Am J Kidney Dis.2017. http://dx.doi.org/10.1053/j.ajkd.2017.02.367

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    2018-02-25 cmj8wellington

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    2017-04-19 neurowu

    #发育#

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    2017-04-19 cmsvly

    #不良妊娠结局#

    0

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    2017-04-19 gwc389

    #kidney#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2012207, encodeId=a3e4201220e46, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Feb 25 15:52:00 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347158, encodeId=9162134e1584a, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Wed Apr 19 10:52:00 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392916, encodeId=184b13929167b, content=<a href='/topic/show?id=8c9f4492370' target=_blank style='color:#2F92EE;'>#妊娠结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44923, encryptionId=8c9f4492370, topicName=妊娠结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fa82500120, createdName=12498a1cm67暂无昵称, createdTime=Wed Apr 19 10:52:00 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469449, encodeId=a0e8146944917, content=<a href='/topic/show?id=850120501c5' target=_blank style='color:#2F92EE;'>#不良妊娠结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20501, encryptionId=850120501c5, topicName=不良妊娠结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa987034131, createdName=cmsvly, createdTime=Wed Apr 19 10:52:00 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603029, encodeId=f08f160302979, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e18990621, createdName=gwc389, createdTime=Wed Apr 19 10:52:00 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188417, encodeId=6dce18841e1c, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Tue Apr 18 07:41:52 CST 2017, time=2017-04-18, status=1, ipAttribution=)]
    2017-04-18 tofsw

    学习了谢谢分享

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