AACE 2016:使用PET/CT诊断高危肾上腺恶性肿瘤时应谨慎

2016-05-30 Mechront 译 MedSci原创

近期一项研究结果表明,18F-氟脱氧葡萄糖(18FDG)PET / CT成像对肾上腺恶性肿瘤高危患者判断的敏感性和特异性较低,还需要联合临床判断。 梅奥诊所内分泌研究员Danae Delivanis博士和同事对352名(男性占62.5%,平均年龄68岁(18-91岁))患者进行了回顾性研究,探究18FDG-PET/CT成像技术对肾上腺恶性肿瘤高危人群的有效性。所有患者在1994-2014年间

近期一项研究结果表明,18F-氟脱氧葡萄糖(18FDG)PET / CT成像对肾上腺恶性肿瘤高危患者判断的敏感性和特异性较低,还需要联合临床判断。

梅奥诊所内分泌研究员Danae Delivanis博士和同事对352名(男性占62.5%,平均年龄68岁(18-91岁))患者进行了回顾性研究,探究18FDG-PET/CT成像技术对肾上腺恶性肿瘤高危人群的有效性。所有患者在1994-2014年间因可疑或确诊肾上腺恶性肿瘤而进行了肾上腺活检。其中恶性肾上腺病变有223例,良性病变有129例。

CT平扫>15 HU时恶性病变的敏感性为100%,特异性为33%,阳性预测值为72%,阴性预测值为100%。进行18FDGPET/CT扫描的92名患者中,44名为转移瘤,3名为恶性淋巴瘤,2名为肾上腺皮质癌,还有43名为肾上腺腺瘤。FDG摄取在恶性组(SUV max:中位数, 10.1;范围, 1.9-29.4)比良性组(SUV max:中位数, 3.7;范围, 1.4-24.5; P < .001)更高。肾上腺/肝比值在恶性组明显高于良性组(中位数, 3; 范围, 0.5-13.4 vs. 中位数, 1.15;范围 0.6-6.6; P < .001)。当肾上腺/肝比值为1.8时,肾上腺肿瘤的诊断最为准确,敏感性为83.3%,特异性为83.7%,阳性预测值为81.8%,阴性预测值为85.1%。

“当CT的HU<10时,可以安全的排除掉肾上腺恶性肿瘤,之后可以进行PET扫描,”Delivanis说,“但是当肾上腺/肝比值超过1.8 SUV max时,PET的敏感性只有83%、84%,所以还要联合临床判断。”

原始出处:

Delivanis D, et al. Abstract #144. Presented at: The American Association for Clinical Endocrinologists Annual Scientific & Clinical Congress; May 25-29, 2016; Orlando, Fla.

Diagnostic PET/CT should be used with caution in high-risk adrenal cases.Healio.May 29, 2016

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    2017-03-28 shanyongle
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    2017-04-23 zgwhgch
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    2016-09-01 feather89
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topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Wed Jun 01 07:08:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87912, encodeId=7e868e9126b, content=再来看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn//images/medsci_toux.jpg, createdBy=7af91730839, createdName=足球疯子, createdTime=Tue May 31 21:08:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87776, encodeId=da6a8e77607, content=挺不错的, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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  5. 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topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Wed Jun 01 07:08:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87912, encodeId=7e868e9126b, content=再来看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn//images/medsci_toux.jpg, createdBy=7af91730839, createdName=足球疯子, createdTime=Tue May 31 21:08:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87776, encodeId=da6a8e77607, content=挺不错的, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/25/ba882cb566d3be250a05e2a69b80f2c9.jpg, createdBy=32881678798, createdName=小M医师, createdTime=Tue May 31 11:16:00 CST 2016, time=2016-05-31, status=1, ipAttribution=)]
    2016-09-15 舒心和人

    不能完全依赖仪器检查

    0

  6. 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createdBy=5ca229920897, createdName=zgwhgch, createdTime=Sun Apr 23 22:08:00 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726112, encodeId=87e61e26112b1, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Sep 01 03:08:00 CST 2016, time=2016-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895064, encodeId=ebb218950644e, content=<a href='/topic/show?id=ce478241e0b' target=_blank style='color:#2F92EE;'>#肾上腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, 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authenticateStatus=null, createdAvatar=, createdBy=53751677671, createdName=沉心多思, createdTime=Thu Jun 02 02:36:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309666, encodeId=6bab130966633, content=<a href='/topic/show?id=412114080d1' target=_blank style='color:#2F92EE;'>#PET/CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14080, encryptionId=412114080d1, topicName=PET/CT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Wed Jun 01 07:08:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331046, encodeId=5c5c133104680, content=<a href='/topic/show?id=15e2140e438' target=_blank style='color:#2F92EE;'>#PET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Wed Jun 01 07:08:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87912, encodeId=7e868e9126b, content=再来看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn//images/medsci_toux.jpg, createdBy=7af91730839, createdName=足球疯子, createdTime=Tue May 31 21:08:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87776, encodeId=da6a8e77607, content=挺不错的, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/25/ba882cb566d3be250a05e2a69b80f2c9.jpg, createdBy=32881678798, createdName=小M医师, createdTime=Tue May 31 11:16:00 CST 2016, time=2016-05-31, status=1, ipAttribution=)]
    2016-06-02 沉心多思

    好文章,得多学习了!

    0

  7. 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topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Wed Jun 01 07:08:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87912, encodeId=7e868e9126b, content=再来看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn//images/medsci_toux.jpg, createdBy=7af91730839, createdName=足球疯子, createdTime=Tue May 31 21:08:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87776, encodeId=da6a8e77607, content=挺不错的, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/25/ba882cb566d3be250a05e2a69b80f2c9.jpg, createdBy=32881678798, createdName=小M医师, createdTime=Tue May 31 11:16:00 CST 2016, time=2016-05-31, status=1, ipAttribution=)]
  8. 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topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Wed Jun 01 07:08:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87912, encodeId=7e868e9126b, content=再来看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn//images/medsci_toux.jpg, createdBy=7af91730839, createdName=足球疯子, createdTime=Tue May 31 21:08:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87776, encodeId=da6a8e77607, content=挺不错的, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/25/ba882cb566d3be250a05e2a69b80f2c9.jpg, createdBy=32881678798, createdName=小M医师, createdTime=Tue May 31 11:16:00 CST 2016, time=2016-05-31, status=1, ipAttribution=)]
    2016-06-01 智慧医人
  9. 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topicName=null, topicId=null, topicList=[TopicDto(id=14074, encryptionId=15e2140e438, topicName=PET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Wed Jun 01 07:08:00 CST 2016, time=2016-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87912, encodeId=7e868e9126b, content=再来看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn//images/medsci_toux.jpg, createdBy=7af91730839, createdName=足球疯子, createdTime=Tue May 31 21:08:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87776, encodeId=da6a8e77607, content=挺不错的, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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    2016-05-31 足球疯子

    再来看看

    0

  10. 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    2016-05-31 小M医师

    挺不错的

    0

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