JCO：PET/CT检查可发现远端转移鼻咽癌

2013-08-13 青楚 cmt

我国学者的一项研究显示，与接受常规检查的鼻咽癌（NPC）患者相比，接受PET/CT检查可以发现更多选段转移的鼻咽癌病例。获益最大的患者为N2-3期疾病和EBV DNA≥ 4000拷贝数/ml的病人群体。相关论文发表于《临床肿瘤学杂志》（JCO）。【原文下载】该前瞻性研究连续招募NPC患者，治疗前对其进行PET/CT、常规检查（CWU）和血清EBV DNA定量测试。

我国学者的一项研究显示，与接受常规检查的鼻咽癌（NPC）患者相比，接受PET/CT检查可以发现更多选段转移的鼻咽癌病例。获益最大的患者为N2-3期疾病和EBV DNA≥ 4000拷贝数/ml的病人群体。相关论文发表于《临床肿瘤学杂志》（JCO）。【原文下载】

该前瞻性研究连续招募NPC患者，治疗前对其进行PET/CT、常规检查（CWU）和血清EBV DNA定量测试。随后我们评估了这些手段的准确性，并比较了不同诊断手段之间的费用差异。

结果显示，纳入研究的583例患者中，共发现86例（14.8）患者存在远端转移，其中由PET/CT手段检出71例（82.6%），CWU手段检出31例（36.0%）。多变量分析表明，N晚期及治疗前EBV DNA水平为远端转移的显著风险因素。对于极低风险患者的远端转移检测，PET/CT并不由于CWU，但对于低风险患者及中等风险患者，PET/CT优于CWU（中低风险患者分别指：N0-1期，EBV DNA≥ 4000拷贝数/ml；N2-3期，EBV DNA≮4000拷贝数/ml）。

原始出处：

Tang LQ, Chen QY, Fan W, Liu H, Zhang L, Guo L, Luo DH, Huang PY, Zhang X, Lin XP, Mo YX, Liu LZ, Mo HY, Li J, Zou RH, Cao Y, Xiang YQ, Qiu F, Sun R, Chen MY, Hua YJ, Lv X, Wang L, Zhao C, Guo X, Cao KJ, Qian CN, Zeng MS, Mai HQ.Prospective Study of Tailoring Whole-Body Dual-Modality [18F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography With Plasma Epstein-Barr Virus DNA for Detecting Distant Metastasis in Endemic Nasopharyngeal Carcinoma at Initial Staging.J Clin Oncol. 2013 Aug 10;31(23):2861-9. doi: 10.1200/JCO.2012.46.0816. Epub 2013 Jul 15.【原文下载】

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2014-06-03 feather89

#PE#

24 0
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2014-05-08 lidong40

#JCO#

24 0
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2013-11-06 lixiaol

#远端转移#

24 0
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2013-08-15 chaojitidian

#PET/CT#

38 0
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2013-08-15 ms7514935887898259

#PET#

20 0
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2013-08-15 kzlchina

#CT检查#

26 0
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2013-08-15 july_978

#PET/CT检查#

33 0

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