Semin Arthritis Rheu:类风湿性关节炎、银屑病关节炎和银屑病预测心脏事件的心血管危险因素

2018-04-01 xiangting MedSci原创

女性RA患者和银屑病的额外心血管风险升高,而不是PsA。RA的全身炎症指标较高,而不是银屑病,表明这些病存在不同的心血管风险介质。

类风湿性关节炎(RA)患者的心血管风险升高已得到确认。仅检查传统的心血管危险因素会低估RA的心血管风险。由红细胞沉降率或C反应蛋白测量的全身炎症也是主要危险因素。然而,传统心血管危险因素(如肥胖和高脂血症),与炎症相比的作用在银屑病关节炎(PsA)和RA中仍不确定。这篇文章分析了RA、PsA、银屑病和对照组的主要心脏不良事件(MACE)发病率,并调整了危险因素,如炎症和疾病改善抗风湿药物以更好地定义心血管风险。

使用Secure Anonymised Information Linkage数据库(包括从1999年到2013年常规收集的威尔士健康数据),对RA患者(n = 8650),PsA(n = 2128)和银屑病(n = 24630),与对照组(n = 1187706)中的MACE发病率和首次发生率进行了比较。

RA、PsA和银屑病患者的传统心血管危险因素高于对照组。在对这些因素进行调整后,仅有女性RA患者(HR:1.3,95%CI:1.0-1.7,p = 0.047)和银屑病(HR:1.2,95%CI:1.0-1.4,p = 0.022)的额外心血管风险显著升高,PsA无统计学意义(HR:1.5,95%CI:0.9-2.5,p = 0.126)。RA患者的ESR和CRP升高,但银屑病患者不升高。

女性RA患者和银屑病的额外心血管风险升高,而不是PsA。RA的全身炎症指标较高,而不是银屑病,表明这些病存在不同的心血管风险介质。

原始出处:

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topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Apr 03 06:39:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483487, encodeId=7917148348e88, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Tue Apr 03 06:39:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629772, encodeId=6df81629e72bb, content=<a href='/topic/show?id=28c351e80dc' target=_blank style='color:#2F92EE;'>#心血管危险#</a>, beContent=null, objectType=article, channel=null, 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    2018-04-03 lmm397
  5. 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  6. 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  7. 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    2018-04-03 zhaojie88
  8. 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