Eur Heart J:终末期肾病患者动静脉瘘术后长期心血管变化如何?

2017-03-12 xing.T MedSci原创

在长期随访中,AVF/AVGs建立以及透析开始后会发生RV重构和功能异常,尽管通过透析改善左室压力负荷控制。右心结构和功能的有害影响会导致HF的发展和死亡风险增加。需要进一步的研究以确定不利的AVF/AVGs变化风险最大的患者,这些患者可能从透析替代形式或将存在的AVF进行结扎中受益。

短期研究已经报道经外科手术建立的动静脉瘘(AVF)或动静脉移植(AVGs)后会发生左心室(LV)扩张,但慢性心脏结构和功能的改变以及AVF/AVGs之后发生的相关临床结局尚未被评估。近日,心血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员试图描述归纳因血液透析而建立分流的患者心脏结构和功能的长期变化情况。

研究人员在因血液透析而经外科手术建立AVF/AVGs的患者中进行了一项回顾性分析,这些患者在手术前后进行了超声心动图检查。137例患者在行AVF之前和行AVF之后2.6年(中位数)进行了超声心动图检查。

AVF建立后开始血液透析,研究人员发现患者血压、体重和估计的血浆容量以及中度逆转的左室重塑有所降低。与此相反,AVF/AVGs的建立与明显的右心室(RV)扩张和右心室功能恶化有关。在伴有更大RV重构的患者中有43%的患者发生HF。手术建立AVF/AVGs之后发生的RV扩张与死亡风险增加独立相关[风险比为3.9,95%可信区间为1.7-9.2,P=0.001]。

在长期随访中,AVF/AVGs建立以及透析开始后会发生RV重构和功能异常,尽管通过透析改善左室压力负荷控制。右心结构和功能的有害影响会导致HF的发展和死亡风险增加。需要进一步的研究以确定不利的AVF/AVGs变化风险最大的患者,这些患者可能从透析替代形式或将存在的AVF进行结扎中受益。

原始出处:

Yogesh N. V. Reddy, et al. Long-term cardiovascular changes following creation of arteriovenous fistula in patients with end stage renal disease. Eur Heart J.https://doi.org/10.1093/eurheartj/ehx045

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    2017-03-14 fusion
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    2017-03-14 zhaojie88
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1693448, encodeId=c28c16934482c, content=<a href='/topic/show?id=7e2de81588c' target=_blank style='color:#2F92EE;'>#终末期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78158, encryptionId=7e2de81588c, topicName=终末期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f6429431807, createdName=anminleiryan, createdTime=Sat May 27 08:25:00 CST 2017, time=2017-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025802, encodeId=08e320258023c, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Sat Sep 02 02:25:00 CST 2017, time=2017-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697420, encodeId=f9ea169e42034, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Tue Mar 14 02:25:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356185, encodeId=ed56135618538, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Mar 14 11:25:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1476348, encodeId=39c714e6348c8, content=<a href='/topic/show?id=eb69e81665d' target=_blank style='color:#2F92EE;'>#终末期肾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78166, encryptionId=eb69e81665d, topicName=终末期肾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fb27278676, createdName=zengjiayao, createdTime=Tue Mar 14 11:25:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480648, encodeId=3af91480648ad, content=<a href='/topic/show?id=f8e23336379' target=_blank style='color:#2F92EE;'>#动静脉瘘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33363, encryptionId=f8e23336379, topicName=动静脉瘘)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=26467645493, createdName=124988c7m97暂无昵称, createdTime=Tue Mar 14 11:25:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562451, encodeId=527a1562451c4, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Tue Mar 14 11:25:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179525, encodeId=15b31e9525ba, content=!!!!!!!!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=078f1661649, createdName=wei834766788, createdTime=Mon Mar 13 08:21:27 CST 2017, time=2017-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=179483, encodeId=810a1e94830f, content=学习新知识谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Mon Mar 13 07:30:03 CST 2017, time=2017-03-13, status=1, ipAttribution=)]
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    2017-03-13 wei834766788

    !!!!!!!!!!

    0

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    2017-03-13 刘煜

    学习新知识谢谢分享

    0

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