KIDNEY INT:非透析依赖性慢性肾脏病患者的身体组成与临床结局相关!

2017-11-05 xing.T MedSci原创

因此,在非透析依赖的CKD患者中,瘦肉组织指数比BMI能更好的提供风险预测。高瘦肉/脂肪组织指数似乎与最佳结局相关。进一步研究需要确定可以改善CKD预后的最佳机体成分。

非透析依赖性慢性肾脏病(CKD)患者的体重指数(BMI)与死亡率之间存在负相关关系(肥胖悖论)。然而,目前尚不清楚增加肌肉质量或体脂是否有助于提高生存率。为了解决这个问题,近日,肾脏病领域权威杂志kidney international上发表了一篇研究文章,研究人员分析了326例3-5期CKD但尚未进行透析的患者身体组成对死亡或心血管事件综合结局的影响。

研究人员利用多频生物电阻抗光谱为主体人体成分监测仪测定精瘦体重和身体脂肪,并表示为瘦肉组织或脂肪组织指数。患者分为高(中位数以上)或低(中位数以下)BMI,高或低瘦肉指数,或高或低脂肪组织指数。

研究人员对受试者中位随访4.6年后,死亡受试者有40例,发生心血管事件的有68例。在Cox比例风险模型中,高瘦肉组织指数,而不是高BMI或高脂肪组织指数,可以预测较低的复合事件或其组分结局的风险(以低于中位数为对照)。基于精肉和脂肪组织指数,当患者被进一步分为四个不同的身体组成组别后,只有高瘦肉/脂肪组织指数组有显著较低的复合终点风险(风险比为0.36,95%可信区间为0.14-0.87;以低瘦肉/脂肪组织指数组为对照)。

因此,在非透析依赖的CKD患者中,瘦肉组织指数比BMI能更好的提供风险预测。高瘦肉/脂肪组织指数似乎与最佳结局相关。进一步研究需要确定可以改善CKD预后的最佳机体成分。

原始出处:


Ting-Yun Lin,et al. Body composition is associated with clinical outcomes in patients with non–dialysis-dependent chronic kidney disease.kidney-international.2017. http://dx.doi.org/10.1016/j.kint.2017.08.025

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    2017-11-07 gwc389
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    2017-11-05 131****1460

    学习了受益匪浅

    0

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    2017-11-05 李东泽

    是很好的学习材料.不错.以后会多学习.

    0

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    2017-11-05 惠映实验室

    学习了.谢谢.

    0

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