Neurology:乌干达周围神经病变以及风险因素研究

2017-07-06 zhangfan MedSci原创

周围神经病变在乌干达农村的成年人中比较常见并且与功能性疾病相关。年龄、女性和HIV感染显著增加神经病变的风险

近日研究人员在乌干达农村考察成人周围神经病相关的患病率、危险因素和功能损害情况。

研究招募了800名参与者,其中,400名HIV阴性参与者,400名未接受抗病毒治疗的HIV阳性参与者,对参与者进行详细的神经学评估,包括评估神经症状、功能措施以及神经功能评价。神经系统疾病的定义是超过1项主观症状或检查神经病变数超过1。采用对数二项回归评估神经病变的危险因素。

参与者平均年龄35岁。神经系统疾病发病率为13%,且HIV阳性患者神经病变高于HIV阴性患者 (19% vs 7%, p < 0.001)。高龄 (RR 1.04, 95% CI 1.02–1.06), 女性 (RR 1.49, 95% CI 1.04–2.15), HIV 感染(RR 2.82, 95% CI 1.86–4.28), 吸烟(RR 1.59, 95% CI 1.02–2.48)以及神经毒性药物史(RR 2.08, 95% CI 1.07–4.05) 是神经病变的显著预测因子。年龄是唯一的神经病变的危险因素,无论HIV阳性(RR 1.03, 95% CI 1.01–1.05)或阴性(RR 1.06, 95% CI 1.02–1.10)参与者。 在所有参与者中,神经病变与多个功能状态受损有关。

研究表明周围神经病变在乌干达农村的成年人中比较常见并且与功能性疾病相关。年龄、女性和HIV感染显著增加神经病变的风险。

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    2018-03-09 yinhl1978
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    2017-07-08 1dd8c52fm63(暂无匿称)

    了解了解

    0

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    2017-07-07 axin012
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  6. [GetPortalCommentsPageByObjectIdResponse(id=2000024, encodeId=b9432000024ec, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Mar 09 10:29:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748252, encodeId=16d71e48252b3, content=<a href='/topic/show?id=15b33952464' target=_blank style='color:#2F92EE;'>#周围神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39524, encryptionId=15b33952464, topicName=周围神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f00136108751, createdName=Smile2692, createdTime=Sun Nov 19 15:29:00 CST 2017, time=2017-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219858, encodeId=84bf2198584f, content=了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Jul 08 09:00:06 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491274, encodeId=d4d614912e41d, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Fri Jul 07 23:29:00 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1500352, encodeId=22d015003521c, content=<a href='/topic/show?id=ecdfe438970' target=_blank style='color:#2F92EE;'>#神经病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74389, encryptionId=ecdfe438970, topicName=神经病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ea69427176, createdName=lingaifan, createdTime=Fri Jul 07 23:29:00 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219168, encodeId=63f82191682a, content=学习了,分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/39b6a0099eb602e8ac1f7e10d5d440a9.jpg, createdBy=dee01724555, createdName=杨利洪, createdTime=Thu Jul 06 13:47:33 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219126, encodeId=b5ed219126c6, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Jul 06 10:07:52 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219100, encodeId=4b2b219100b7, content=学习,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Thu Jul 06 09:22:38 CST 2017, time=2017-07-06, status=1, ipAttribution=)]
    2017-07-06 杨利洪

    学习了,分享了

    0

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    2017-07-06 明月清辉

    谢谢分享,学习了

    0

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    2017-07-06 执着追梦

    学习,谢谢分享

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