Gastroenterology ：直接反映腺瘤检测和切除的结肠镜筛查新指标

2018-06-21 zhangfan MedSci原创

研究人员考察了2种全新的直肠癌乙状结肠镜筛查指标，新指标可以直接反映腺瘤的检测和切除，较筛查频率相比能更有效的指导胃肠外科的临床实践过程

乙状结肠镜筛查并进行腺瘤切除可降低结直肠癌(CRC)发病风险。通常以筛查频率作为临床预防的主要指标，很少直接考虑腺瘤切除对CRC风险的影响。近日研究人员考察了需切除腺瘤数目(NNR)及避免腺瘤存在时间(DTA)对结肠癌预防的效果。

研究人员对4项大型乙状结肠镜筛查研究（PLCO、NORCCAP、 SCORE以及UKFSST4项研究）数据进行考察，NNR通过切除腺瘤数量除以CRCs的数量计算。

PLCO、NORCCAP、 SCORE以及UKFSST4项研究中，NNR分别为74、71、27以及36。荟萃分析后平均NNR为52。各研究的DTA范围为278-730患者年，荟萃分析后平均为500患者年。每1000 DTA可减少CRC发病2例。对于非晚期CRC，NNR和 DTA分别为13及122患者年。

研究人员考察了2种全新的直肠癌乙状结肠镜筛查指标，新指标可以直接反映腺瘤的检测和切除，较筛查频率相比能更有效的指导胃肠外科的临床实践过程。

原始出处：

Paul F. Pinsky et al. Number of Adenomas Removed and Colorectal Cancers Prevented in Randomized Trials of Flexible Sigmoidoscopy Screening. Gastroenterology June 20， 2018.

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2019-03-10 ms24272190615788285182

#AST#

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2018-11-22 jktdtl

#Gastroenterol#

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2018-06-29 许安

#GAS#

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2018-06-23 zhouqu_8

#肠镜#

32 0
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2018-06-23 chaojitidian

#Gastroenterology#

27 0
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2018-06-22 1209e435m98(暂无昵称)

学习了.谢谢分享

79 0
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2018-06-21 1dd8c52fm63(暂无匿称)

学习学习.继续关注

74 0
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2018-06-21 医者仁心5538

学习了

68 0

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