AJCN:中心性肥胖测量与HIV患者心血管疾病风险的预测指标高度一致

2018-06-17 MedSci MedSci原创

研究人员发现接受高活性抗逆转录病毒疗法(HAART)的HIV患者体内体脂会重新分布,其代谢异常常会促成动脉粥样硬化,增加心血管疾病风险。本项研究旨在评估找出与HIV患者动脉粥样硬化相关的指标。

背景:研究人员发现接受高活性抗逆转录病毒疗法(HAART)的HIV患者体内体脂会重新分布,其代谢异常常会促成动脉粥样硬化,增加心血管疾病风险。本项研究旨在评估找出与HIV患者动脉粥样硬化相关的指标。

方法:为了评估HIV患者心血管疾病风险,研究人员进行了心电图检查,测量了踝臂指数和血压动脉高压,进行了脂质生化测试,并测量了血糖,并测量了腰围(WC),臀部,大腿,小腿,颈部,躯干和皮褶厚度(肱二头肌,肱三头肌,肩胛下,上髂骨),进行生物电阻抗分析(BIA)和相关指标[体重指数,腰臀比,腰围与小腿比,腰围与身高比(WHtR),躯干与手臂比例,体脂质量校正的体重指数,身体肥胖指数,锥度指数,体形指数,脂肪质量(百分比)和相位角]。

结果: 中心肥胖WC和WHtR测量显示最佳表现 :男性WC(AUC)为0.83(95%CI:0.78,0.89; P  <0.05); 女性的WC AUC:0.86(95%CI:0.81,0.91; P  <0.05); 男性WHTR AUC:0.83(95%CI:0.78,0.88; P  <0.05); 和女性WHtR AUC:0.85(95%CI:0.80,0.91; P  <0.05)。所有肥胖指标均与艾滋病毒血清阴性人群提出的截距不同。WC的临界值为男性为87.75 cm(敏感度为82.2%,特异度为75.5%),女性为90.5 cm(敏感度为84.0%;特异度为73.0%)。

结论:中心性肥胖的测量指标与心血管疾病风险的预测因子呈显着的相关性,并且本研究中提出的临界点的使用旨在有助于及早发现心血管疾病风险的增加,从而实现早期干预。

原始出处:
Rebeca A Beraldo.et al.Anthropometric measures of central adiposity are highly concordant with predictors of cardiovascular disease risk in HIV patients. The American Journal of Clinical Nutrition.2018.

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    2018-09-25 苏小雨

    学习了学习了

    0

  3. 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    2018-06-19 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

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likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun Jun 17 19:19:08 CST 2018, time=2018-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324987, encodeId=232332498e98, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Jun 17 19:12:09 CST 2018, time=2018-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324961, encodeId=c527324961b6, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jun 17 15:34:59 CST 2018, time=2018-06-17, status=1, ipAttribution=)]
    2018-06-17 changjiu

    学习一下谢谢

    0

  8. 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likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun Jun 17 19:19:08 CST 2018, time=2018-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324987, encodeId=232332498e98, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Jun 17 19:12:09 CST 2018, time=2018-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324961, encodeId=c527324961b6, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jun 17 15:34:59 CST 2018, time=2018-06-17, status=1, ipAttribution=)]
    2018-06-17 中医痴

    不错的.学习了.谢谢分享.

    0

  9. 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encodeId=c527324961b6, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jun 17 15:34:59 CST 2018, time=2018-06-17, status=1, ipAttribution=)]
    2018-06-17 清风拂面

    谢谢分享学习

    0

  10. 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    2018-06-17 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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