Clinica Chimica Acta：microRNA-34a通过下调c-Met抑制人晶状体上皮细胞的增殖和迁移

2019-09-22 gladiator MedSci原创

microRNA (miRNAs)是一种内源性表达的非编码小RNA，通过与靶mRNA结合抑制蛋白质翻译

microRNA (miRNAs)是一种内源性表达的非编码小RNA，通过与靶mRNA结合抑制蛋白质翻译。最近的研究表明，miRNA参与了多种细胞结构和功能的调控，包括细胞增殖和迁移的调控。microRNA-34a (miR-34a)是p53抑癌基因的潜在效应因子，其抑制细胞生长的作用已被广泛研究。在本研究中，我们研究了miR-34a在人类晶状体上皮细胞中的功能。后确认miR-34a P53依赖的方式表达增加人类晶状体上皮细胞与阿霉素治疗之后，我们证明了过表达miR-34a人类晶状体上皮细胞系及B3导致细胞增殖和迁移明显降低，研究同时使用了MTS和transwell迁移化验。此外，HGF还能促进人晶状体上皮细胞的增殖和迁移。Western blot检测发现miR-34a可以下调c-Met蛋白的表达。此外，miR-34a过表达下调磷酸化Akt、磷酸化ERK1/2等细胞周期调控因子的水平。miR-34a在PCO临床标本中表达显著降低。

这些结果表明miR-34a可能通过下调c-Met调控人晶状体上皮细胞增殖和迁移，从而在PCO中发挥抑制作用。

原始出处：

Dong Feng，Ning Zhu，MicroRNA-34a suppresses human lens epithelial cell proliferation and migration via downregulation of c-Met

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2020-03-29 jiafufeng@yaho

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2020-01-13 一闲

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2020-06-12 ms8888626721583891

#迁移#

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2019-12-09 xjy02

#Micro#

32 0
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2020-09-05 天堂的云

#c-Met#

28 0
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2020-07-12 windight

#CTA#

26 0
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2019-09-24 zhouqu_8

#microRNA#

26 0
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2019-09-24 lizhou0208

#上皮细胞#

26 0

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Clinica Chimica Acta：microRNA-34a通过下调c-Met抑制人晶状体上皮细胞的增殖和迁移

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