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J Endod：MAPK信号通路对脂多糖介导的根尖牙乳头来源干细胞成骨/牙本质分化的影响

2019-02-15 lishiting MedSci原创

SCAP增殖分化MAPK
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人根尖牙乳头来源干细胞(SCAPs)的成牙本质分化是未发育完成牙齿牙根发育的必不可少的步骤。然而，炎症状态对SCAPs成骨/成牙本质分化的影响还未可知。这篇研究的目的是为了评估脂多糖(LPS)对SCAPs增殖和成骨/成牙本质分化的影响以及MAPK信号通路在LPS介导的SCAPs成骨/成牙本质分化中的作用。

人根尖牙乳头来源干细胞(SCAPs)的成牙本质分化是未发育完成牙齿牙根发育的必不可少的步骤。然而，炎症状态对SCAPs成骨/成牙本质分化的影响还未可知。这篇研究的目的是为了评估脂多糖(LPS)对SCAPs增殖和成骨/成牙本质分化的影响以及MAPK信号通路在LPS介导的SCAPs成骨/成牙本质分化中的作用。研究培养了从人第三磨牙获取的SCAPs。检测细胞活力以及碱性磷酸酶活性和矿化能力。在SCAPs成骨/成牙本质分化过程中评估成骨/成牙本质分化和MAPK信号通路相关基因的表达变化。结果显示，在0.1 μg/mL LPS组中，SCAPs的细胞增殖、ALP活性和矿化明显上调。实时定量聚合酶链式反应检测显示，DSPP、Runx2和BSP表达升高。然而，并未发现任何OCN的表达变化。另外，LPS刺激上调了SCAPs内p-ERK和p-p38的表达，并且抑制ERK和p38 MAPK通路显著阻断LPS诱导的SCAPs的分化。结论：结果显示，LPS在适当的浓度会促进SCAPs的增殖和成骨/成牙本质分化。ERK和p38 MAPK通路参与了LPS介导的SCAPs成骨/成牙本质分化的调控。原始出处：Liu J

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    2019-12-11 lidong51

    #MAPK#

    0

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    2019-02-17 zhaojie88

    #成骨#

    0

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    2019-02-17 小刀医生

    #脂多糖#

    0

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    2019-02-17 ms8538335253054589

    #牙本质#

    0

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    2019-02-17 wgx310

    #信号通路#

    0

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