CHEST:OSA的严重程度是房颤发生的独立预测因子

2015-11-02 崔倩 译 MedSci原创

OSA已经是和房颤(AF)相关的常见现象,但来自大型纵向队列数据建立OSA是否是AF独立于肥胖和其他已经建立风险的风险因素的数据还很少。研究人员在1989年和2001年间招募了患者参与睡眠门诊简称为实验室多导睡眠图监测可能的OSA。1970年至2009年之间西澳大利亚全部的人群住院数据被链接到睡眠研究病例中,以确定住院治疗至2009年AF事件。Cox回归分析被用来评估OSA与事件AF的独立相关性。

阻塞性睡眠呼吸暂停(OSA)已被证实是和房颤(AF)相关的常见现象,但来自大型纵向队列数据关于OSA是否是AF独立于肥胖和其他已经建立风险的风险因素的数据还很少。

研究人员在1989年和2001年间招募了患者参与睡眠门诊简称为实验室多导睡眠图监测可能的OSA。1970年至2009年之间西澳大利亚全部的人群住院数据被链接到睡眠研究病例中,以确定住院治疗至2009年AF事件。Cox回归分析被用来评估OSA与事件AF的独立相关性。

研究对象(6841)以中年人(48.3±12.5岁)和男性(77%)为主,在平均11.9年的随访过程中发生455例房颤。AF的单变量预测因素包括年龄、体重指数、高血压、糖尿病、心脏瓣膜病、冠心病或外周动脉疾病、心脏衰竭、慢性阻塞性肺病(所有P<0.001)。多变量调整后,AF事件的独立预测因子分别为呼吸暂停/低通气指数(AHI)>5/小时(危险比(HR),1.55;95%Cl,1.21-2.00),log(AHI+1)(HR,1.15 ;95%Cl,1.06-1.26),和log(氧饱和度时间<90%+1)(HR,1.12;95%Cl,1.06-1.19)。对于房颤的发生、年龄、性别、或体重指数以及AHI之间没有相互作用。

OSA的诊断和严重性与AF事件独立相关。还需要临床试验确定是否治疗OSA将减少房颤的负担。

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    2016-05-02 Smile2680
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    2015-11-04 bioon3

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