Hypertension:糖尿病前期患者合并高血压时心血管意外风险会显著增大

2018-04-21 MedSci MedSci原创

糖尿病前期(Pre-DM)单独或合并高血压是否是心血管疾病的独立危险因素尚未完全明确。Hypertension杂志近期发表一篇相关文献。研究人员对Pre-DM与心血管疾病的关系是否与患者有无高血压而有所不同进行进一步探究。本研究共对7121例进行冠状动脉造影检查的心绞痛样胸痛患者进行评估,并招募了4193位冠状动脉造影确诊的稳定性、新发冠状动脉疾病患者。根据患者的糖尿病程度将其分为3组,并根据有无

糖尿病前期(Pre-DM)单独或合并高血压是否是心血管疾病的独立危险因素尚未完全明确。Hypertension杂志近期发表一篇相关文献。

研究人员对Pre-DM与心血管疾病的关系是否与患者有无高血压而有所不同进行进一步探究。本研究共对7121例进行冠状动脉造影检查的心绞痛样胸痛患者进行评估,并招募了4193位冠状动脉造影确诊的稳定性、新发冠状动脉疾病患者。根据患者的糖尿病程度将其分为3组,并根据有无高血压进一步分层。

通过病变血管的数量和Gensini评分评估冠状动脉疾病的严重程度。对所有研究对象进行规律随访,以获得复合终点的发生情况。

平均随访11338个患者年,共发生434例(10.35%)心血管事件。Pre-DM组和血糖控制正常组之间冠脉病变程度和复合终点未观察到显著差异(p>0.05)。但是,将高血压纳入分层因素时,Pre-DM合并高血压和DM合并高血压组的心血管疾病风险(以冠脉严重程度和临床诊断评估)明显增加(p<0.05)。

本研究结果表明对于稳定性、新发冠状动脉疾病患者,Pre-DM患者心血管疾病风险增高主要是由于合并高血压,而不是Pre-DM本身引起。

原始出处:

Hui-Hui Liu,et al.Impacts of Prediabetes Mellitus Alone or Plus Hypertension on the Coronary Severity and Cardiovascular Outcomes.Hypertension. April 18,2018.https://doi.org/10.1161/HYPERTENSIONAHA.118.11063

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