Int J Cancer:癌症后怀孕的妊娠结局大多令人欣慰,但这些癌症仍需密切监测

2017-08-30 MedSci MedSci原创

2015年欧洲癌症大会(ECC)上发布的一则研究结果表明,对于那些早期暴露于癌症及癌症相关影像学检查及治疗的胎儿来说,其18-36周的生长发育情况似乎跟正常情况的胎儿无异。该项研究发表在2015年9月《新英格兰医学杂志》(NEJM)上。研究显示化疗对产后婴儿的生长发育、认知或心脏功能还没有明确的影响。但该研究只纳入了129例来自比利时、荷兰、意大利和捷克共和国的儿童作为观察组(产前暴露组),而另设

2015年欧洲癌症大会(ECC)上发布的一则研究结果表明,对于那些早期暴露于癌症及癌症相关影像学检查及治疗的胎儿来说,其18-36周的生长发育情况似乎跟正常情况的胎儿无异。该项研究发表在2015年9月《新英格兰医学杂志》(NEJM)上。研究显示化疗对产后婴儿的生长发育、认知或心脏功能还没有明确的影响。但该研究只纳入了129例来自比利时、荷兰、意大利和捷克共和国的儿童作为观察组(产前暴露组),而另设数量相同的对象作为对照组(无产前暴露)。但是,研究未明确指出癌症暴露对妊娠结局的影响。

本研究中,来自美国的研究人员不仅在怀孕诊断晚于癌症诊断的癌症幸存者和没有癌症的怀孕女性中探讨了癌症幸存者是否有较高风险的异常妊娠结局,还探讨了这些风险是否因癌症类型和人种不同而有所不同。

研究共纳入了来自美国三个州的出生证明的妊娠结局和癌症登记处的诊断。分析仅限于诊断后的第一例、活单胎分娩。根据分娩年龄、胎次、种族/种族和教育程度,在登记处匹配没有癌症诊断的生产过的女性。研究人员使用Log二项回归估计风险比。

宫颈癌的患者有较高的早产风险(风险比  = 2.8,95%CI:2.1-3.7),浸润型乳腺癌幸存者(RR = 1.3,95%CI:1.1-1.7)和白血病幸存者(RR = 2.1,95%CI:1.3-3.5)中也同样风险较高。研究人员还观察到,婴儿小于胎龄儿(SGA)风险(基于国家数据,出生体重低于同胎龄平均体重的10%)在脑肿瘤幸存者(RR = 1.7,95%CI:1.1-2.8)和淋巴结外非霍奇金淋巴瘤(RR = 2.3,95%CI:1.5-3.6)幸存者中较高。

研究人员在被诊断为导管内原位癌、甲状腺癌、黑色素瘤或霍奇金淋巴瘤之后怀孕的女性中未观察到早产、低出生体重儿或SGA婴儿的风险增加。

虽然既往的研究和本研究的结果,对许多怀孕的癌症幸存者是令人欣慰的,但依然有部分癌症女性需要在怀孕期间密切监测。

原始出处:

Hartnett KP, Ward KC,et al.The risk of preterm birth and growth restriction in pregnancy after cancer.Int J Cancer. 2017 Aug 24. doi: 10.1002/ijc.30914. [Epub ahead of print]

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    0

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    2017-08-31 ylzr123

    好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛.

    0

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    2017-08-30 龙胆草

    学习谢谢分享

    0

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    2017-08-30 Julie W

    虽然既往的研究和本研究的结果.对许多怀孕的癌症幸存者是令人欣慰的.但依然有部分癌症女性需要在怀孕期间密切监测.

    0

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    2017-08-30 执着追梦

    学习.谢谢分享

    0

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    2017-08-30 hfuym10906

    学习了学习了学习了学习了学习了学习了学习了学习了学习了学习了学习了

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  8. [GetPortalCommentsPageByObjectIdResponse(id=239561, encodeId=94ba239561b3, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/04/7e2c04a7e58b6065a1392efd799c6a6b.jpg, createdBy=de482077642, createdName=王晓霞, createdTime=Sat Sep 02 06:53:57 CST 2017, time=2017-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392927, encodeId=60f4139292ec3, content=<a href='/topic/show?id=8c9f4492370' target=_blank style='color:#2F92EE;'>#妊娠结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44923, encryptionId=8c9f4492370, topicName=妊娠结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fa82500120, createdName=12498a1cm67暂无昵称, createdTime=Thu Aug 31 16:06:00 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238921, encodeId=67cd238921d7, content=好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛., beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Aug 31 11:03:15 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238586, encodeId=ad9523858629, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Wed Aug 30 08:30:08 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238577, encodeId=ff3f2385e765, content=虽然既往的研究和本研究的结果.对许多怀孕的癌症幸存者是令人欣慰的.但依然有部分癌症女性需要在怀孕期间密切监测., beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Wed Aug 30 08:10:47 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238573, encodeId=c9422385e30e, content=学习.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Wed Aug 30 07:58:42 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238546, encodeId=fe4323854618, content=学习了学习了学习了学习了学习了学习了学习了学习了学习了学习了学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Wed Aug 30 07:17:41 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238532, encodeId=e16a2385328b, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Wed Aug 30 07:00:27 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238510, encodeId=84b923851047, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Wed Aug 30 06:27:14 CST 2017, time=2017-08-30, status=1, ipAttribution=)]
    2017-08-30 189****1577

    值得推荐一下

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    2017-08-30 1e145228m78(暂无匿称)

    学习了谢谢作者分享!

    0

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