Neurosurgery:颈动脉夹层患者可进行血管内治疗

2015-10-26 phylis 译 MedSci原创

背景:颈动脉夹层(CAD)的患者发生急性缺血性卒中(AIS)后血管内治疗的安全和可行性尚不清楚。目的:报道研究者CAD发生AIS患者进行干预措施,并通过系统性综述CAD的静脉溶栓(IVT)等传统治疗和CAD发生AIS的干预措施相比较。方法:回顾性分析来自两个第三中心的狭窄闭塞的CAD患者,患者NIHSS分数>5并且症状持续<12小时。搜索PubMed数据库系统综述CAD患者的进行IVT

背景:颈动脉夹层(CAD)的患者发生急性缺血性卒中(AIS)后血管内治疗的安全和可行性尚不清楚。

目的:对CAD患者发生AIS进行干预措施后,并通过系统性综述,CAD的静脉溶栓(IVT)等传统治疗和CAD发生AIS的干预措施相比较。

方法:回顾性分析来自两个第三中心的狭窄闭塞的CAD患者,患者NIHSS分数>5并且症状持续<12小时。搜索PubMed数据库系统综述CAD患者的进行IVT治疗的研究。

结果:研究期间,进行血管内干预的患者1112名。21名患者满足纳入标准。患者平均年龄52.0 ± 10.9 岁,76% 为男性,NIHSS分数为17.4 ± 5.8; 52% 患者干预前进行IVT 并且90%患者存在串联闭塞。闭塞的平均时间为4.8 ± 2.1小时,处理时间为 1.8 ± 1.0小时。52%的患者应用支架,95%的患者获得再灌注。没有发生实质出血,71%的患者预后良好。8个涉及CAD患者溶栓的研究满足纳入标准(n=133)。与以前报道的IVT相比,研究者进行血管内治疗的患者,NIHSS分数较高(17 vs14),治疗前的时间较长(287 vs 162分钟)。与欧洲合作
急性卒中研究相比,患者症状性脑出血较少(0-6%),预后良好(71%-52%)。

结论:研究为CAD患者发生AIS进行血管内处理的可行性和安全性提供了证据。

原文出处:

Haussen DC, Jadhav A, Jovin T, et al. Endovascular Management vs Intravenous Thrombolysis for Acute Stroke Secondary to Carotid Artery Dissection: Local Experience and Systematic Review. Neurosurgery. 2015,Oct 21.


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    2016-10-06 chg121
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1843396, encodeId=096c184339661, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sat Sep 10 02:13:00 CST 2016, time=2016-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1927036, encodeId=70af192e036a3, content=<a href='/topic/show?id=6b57100540e2' target=_blank style='color:#2F92EE;'>#颈动脉夹层#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100540, encryptionId=6b57100540e2, topicName=颈动脉夹层)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Sat Jun 25 05:13:00 CST 2016, time=2016-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877670, encodeId=1af018e7670f8, content=<a href='/topic/show?id=b013169237f' target=_blank style='color:#2F92EE;'>#surgery#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16923, encryptionId=b013169237f, topicName=surgery)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Thu Oct 06 00:13:00 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2021510, encodeId=91ef2021510c5, content=<a href='/topic/show?id=31e8e9669d' target=_blank style='color:#2F92EE;'>#GER#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7966, encryptionId=31e8e9669d, topicName=GER)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Tue May 24 15:13:00 CST 2016, time=2016-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41754, encodeId=ae0e41e546c, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b911658392, createdName=梦想天空, createdTime=Wed Oct 28 10:14:00 CST 2015, time=2015-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364067, encodeId=f9a1136406e4b, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Wed Oct 28 08:13:00 CST 2015, time=2015-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519508, encodeId=44de1519508b7, content=<a href='/topic/show?id=b63a3323558' target=_blank style='color:#2F92EE;'>#动脉夹层#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33235, encryptionId=b63a3323558, topicName=动脉夹层)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae5711287462, createdName=mhzhuang@stu.e, createdTime=Wed Oct 28 08:13:00 CST 2015, time=2015-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41427, encodeId=83b64142e34, content=赶, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150904/IMG55E8DB68F05883098.jpg, createdBy=e00a1631985, createdName=fengzhigu, createdTime=Tue Oct 27 07:22:00 CST 2015, time=2015-10-27, status=1, ipAttribution=)]
    2015-10-28 梦想天空

    0

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    2015-10-28 lsndxfj
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    2015-10-27 fengzhigu

    0

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心血管疾病或卒中患者中,血清尿酸(UA)的重要性和功能尚不清楚。研究人员旨在评估卒中患者的UA水平以及内源性UA与急性缺血性卒中(AIS)患者临床预后的相关性,尤其是性别和UA水平与AIS预后可能的关系。研究人员筛选了缺血性卒中48h内的患者303名,101名患者进行了溶栓治疗。入院后第二天清晨测量血清UA(μmol/L)。患者预后用发病后90天mRS评估。根据血清UA水平,将患者分为四组。应用二

Cerebrovasc Dis: 无症状性实质出血史患者,静脉溶栓后脑内出血的风险未增加

背景:NINDS试验显示静脉给予rtPA能够改善急性缺血性卒中的神经功能预后。排除了脑内出血(ICH)史的患者,可能是基于这类患者出血的风险增加。然而,是否应反对或支持给予先前存在ICH的患者静脉rtPA溶栓,尚不清楚。研究人员旨在通过一项回顾性基于医院单中心研究确定给予这种患者静脉rtPA溶栓的安全性。方法:研究人员总数了2006年1月到2014年4月间医院卒中中心接受静脉rtPA治疗的所有患者

PLoS One: 评估急性缺血性卒中患者非工作日时间急诊治疗

背景和目的:非工作日时间急性缺血性卒中患者的急诊处理的质量是有争议的。因此,研究人员旨在分析在非工作日时间入院的患者性能指标,治疗治疗以及临床预后。 方法:研究选取了2007年9月到2008年8月在中国国家卒中登记(CNSR)的缺血性卒中患者,共4493名。正常工作日指周一到周五上午8点到下午5点到达急诊部的患者。非工作日时间包括工作日时间剩余事件以及法定假期。运动多变量logistic回归模型分

Cerebrovasc Dis:“卒中房”有助于急性缺血性卒中患者治疗

背景:对于急性缺血性卒中患者,血管内治疗(IAT)被认为是清除结构性斑块的有效措施。因为患者预后主要依赖于治疗的时间(时间就是大脑),研究者评估在动脉内卒中治疗之前,基于时间敏感性(诊断和治疗在一个地方)干预的效果。方法:评估2010年4月26号前后进行IAT的大血管闭塞的急性卒中患者,这些患者诊断和治疗过程都在同一个地方(“卒中房”)。结果:进行干预后,174名患者入院到血管造影的时间显著缩短(

Atherosclerosis: 高强度的他汀治疗改善急性缺血性卒中的预后

背景和目的:目前尚无不同强度的他汀类药物对缺血性卒中患者长期预后影响的研究。研究人员旨在评估这种影响。方法:有436名急性缺血性卒中的出院患者(39.2%男性,年龄78.6 ± 6.7岁)。应用等效剂量的阿托伐他汀进行他汀药物的治疗。出院后一年,应用mRS评估患者的功能状态。不良预后为mRS分数2-6分。记录患者缺血性卒中,心肌梗死以及死亡的发生。结果:与服用阿托伐他汀10 mg/天的患者相比,服

J Am Heart Assoc:高血糖与急性缺血性卒中溶栓后预后的关系

背景:高血糖与急性缺血性卒中(AIS)的不良预后相关,并且可能影响tPA溶栓后的患者预后。研究人员旨在分析急慢性高血糖与tPA治疗的患者临床预后的关系。方法:研究人员筛选2009年到2013年间“跟着指南走——卒中”中接受tPA治疗的来自1408个地方的58265名AIS患者。入院血糖>140 mg/dL,则定义为急性高血糖。血浆糖化血红蛋白(HbA1c)>6.5%,则定义为慢性高血糖