JCLA:嗜中性粒细胞与淋巴细胞比值能预测早产儿晚期败血症吗

2018-05-31 MedSci MedSci原创

嗜中性粒细胞与淋巴细胞比率(NLR)是一种相对比较容易获得的生物标志物,该标志已被报道在成人试验中指示疾病的严重程度。本研究的目的是评估在考虑脓毒症原因的情况下,培养阳性率与NLR之间的关系,以及对活性药物的预测。 将出生体重早产儿≤1500 g和/或≤32孕周的研究对象纳入本研究。所有婴儿的出生后临床和实验室均有脓毒症症状均为3天以上。根据血液培养结果,所有登记的婴儿被分为两组:经培养证

嗜中性粒细胞与淋巴细胞比率(NLR)是一种相对比较容易获得的生物标志物,该标志已被报道在成人试验中指示疾病的严重程度。本研究的目的是评估在考虑脓毒症原因的情况下,培养阳性率与NLR之间的关系,以及对活性药物的预测。

将出生体重早产儿≤1500 g/或≤32孕周的研究对象纳入本研究。所有婴儿的出生后临床和实验室均有脓毒症症状均为3天以上。根据血液培养结果,所有登记的婴儿被分为两组:经培养证实的脓毒症婴儿和疑似脓毒症婴儿。NLR计算为嗜中性粒细胞计数与淋巴细胞计数之比。初步的实验室调查包括白细胞计数、血小板计数(PLT)C‐反应蛋白(CRP)和血液培养。

结果显示,共有127名婴儿参与,其中57例经培养证实的脓毒症,另外75例疑似脓毒症。两组在胎龄、性别、出生体重、分娩方式、产后年龄等方面无显著差异。计算了NLRCRPROC曲线。曲线下的面积与0.78±0.04(NLR)0.55±0.05(CRP)NLR的分界点为1.77,敏感性为0.73,特异性为0.78,准确率为0.76

研究表明,NLR是一种简单、廉价、快速的方法,与CRP一起,在检测经培养证实的脓毒症,以及减少不必要的抗生物治疗方面更为有效。

原始出处:

Senem Alkan Ozdemir,Can neutrophil to lymphocyte ratio predict lateonset sepsis in preterm infants?

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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri Jun 01 05:51:53 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2018-06-02 yfjms

    学习

    0

  5. 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    2018-06-01 明月清辉

    谢谢分享.学习了

    0

  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri Jun 01 05:51:53 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2018-06-01 飛歌

    学习了很有用不错

    0

  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri Jun 01 05:51:53 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2018-06-01 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri Jun 01 05:51:53 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2018-06-01 wzb521zf

    一起学习学习

    0

  9. 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    2018-06-01 lou.minghong

    学习了谢谢分享!

    0

  10. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri Jun 01 05:51:53 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2018-06-01 yfjms

    学习

    0

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本研究旨在利用颅内超声(US)横断面和纵向建立正常神经影像学表现的早产儿小脑体积大小以及2年神经发育结果,并将结果发表在Radiology上。

超声诊断早产儿先天性膈疝一例

患儿男,系孕2次产2次(G2P2)孕35+6周在江苏省淮安市盱眙县中医院因“胎膜早破10h、瘢痕子宫”剖宫产出生

J AAPOS:早产儿晶状体空泡病例报告

加拿大多伦多市儿童医院眼科和视力科学系和多伦多大学眼科与视觉科学系的AlAli A近日在J AAPOS发表了一篇文章,他们报告6例早产儿双侧空泡状晶体混浊,并对这一病理现象进行了详细的描述。

Acta Paediatr:NTpro-BNP对于大于30周龄的早产儿筛查视网膜病变的作用

英国纽卡斯尔大学细胞医学研究所的Berrington JE近日在Acta Paediatr发表了一篇文章,N末端B型利钠肽NTproBNP水平与妊娠30周龄以下的早产儿视网膜病变(ROP)发生相关。符合其他ROP筛查标准的较成熟婴儿的ROP发生率非常低。因此,在这项研究中,作者测试了NTproBNP是否能预测这些婴儿的ROP发展。