Chest：MUC5AC和MUC5B的糖基化变体改变急性哮喘儿童的粘蛋白组分

2017-10-07 MedSci MedSci原创

弥漫性气道粘液阻塞是严重和致命性哮喘的重要特征。 MUC5AC和MUC5B是气道粘液中的主要凝胶形成粘蛋白。气道粘液的粘蛋白组成可能影响其功能特性。研究人员使用Western blotting量化了匹配了年龄的急性和稳定性哮喘及健康对照对照儿童痰液中的主要呼吸道粘蛋白MUC5AC和MUC5B。研究共收集了38名儿童痰液样本（13例急性哮喘，15例稳定型哮喘，10例对照者）。痰液MUC5AC浓度为7

弥漫性气道粘液阻塞是严重和致命性哮喘的重要特征。 MUC5AC和MUC5B是气道粘液中的主要凝胶形成粘蛋白。气道粘液的粘蛋白组成可能影响其功能特性。

研究人员使用Western blotting量化了匹配了年龄的急性和稳定性哮喘及健康对照对照儿童痰液中的主要呼吸道粘蛋白MUC5AC和MUC5B。

研究共收集了38名儿童痰液样本（13例急性哮喘，15例稳定型哮喘，10例对照者）。痰液MUC5AC浓度为7.6μg/ mL，对照组为22.4μg/ mL，哮喘患者为（P = 0.17），哮喘患者为44.7μg/ mL（P <0.05）。对照组、哮喘患者和急性哮喘患者MUC5B浓度分别为238.5、208.4和165.9μg/ mL，差异有统计学意义。急性哮喘患者MUC5AC浓度升高导致对照组与急性哮喘患者MUC5B：MUC5AC比值明显升高（P <0.05）。各组之间MUC5B糖形态存在明显差异，低电荷糖型仅存在于急性哮喘患者中。

总之，该研究结果表明，增加的MUC5AC和存在低电荷MUC5B糖型显著改变了急性哮喘儿童的粘蛋白组成。这些变化可能是急性哮喘期间观察到的气道粘液阻塞的重要因素。

原始出处：

Kathryn G. Welsh, Karine Rousseau, et al., MUC5AC and a Glycosylated Variant of MUC5B Alter Mucin Composition in Children With Acute Asthma. Chest, October 2017Volume 152, Issue 4, Pages 771–779

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2018-04-13 xiangyuzhou971

#EST#

35 0
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2017-12-13 Smile2680

#Chest#

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2017-10-09 lfyang

#糖基化#

39 0
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2017-10-07 hhh678

henhao

64 0
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2017-10-07 忠诚向上

好好努力学习

61 0
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2017-10-07 有备才能无患

弥漫性气道粘液阻塞是严重和致命性哮喘的重要特征.MUC5AC和MUC5B是气道粘液中的主要凝胶形成粘蛋白.气道粘液的粘蛋白组成可能影响其功能特性.

64 0
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2017-10-07 183****7028

学习

88 0
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2017-10-07 中医痴

不错的.学习了.谢谢分享.

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