Sci Rep:结缔组织病患者的左心室变形

2019-12-18 xiangting MedSci原创

这项研究表明,尽管保留了LVEF,CTD患者仍表现出异常的LV变形。IIM与非IIM患者的LV变形损害有所不同。

这项研究目的是评估结缔组织病患者(CTD)的左心室(LV)心肌劳损,并比较特发性炎症性肌病(IIM)与非IIM亚组的LV变形。

入选了98CTD患者,其中包括56IIM患者和42名非IIM患者,以及30名健康受试者,并进行3.0T心脏磁共振成像(MRI)扫描。测量和评估了左室功能和应变参数。

研究结果表明,CTD患者左心室射血分数保留(60.85%),并且径向、周向和纵向的总体和区域峰值应变(PS)明显降低(p<0.05)。IIM患者的总体纵向PSGLPS)和心尖部纵向PS明显降低,而非IIM患者的所有应变参数均下降。除了GLPS和心尖部纵向PS外,非IIM患者的所有应变参数均低于IIM患者。通过Pearson相关性分析,IIM和非IIM患者的LV总体径向和周向PS均与N-末端前脑利钠肽水平和LV射血分数相关。

这项研究表明,尽管保留了LVEFCTD患者仍表现出异常的LV变形。IIM与非IIM患者的LV变形损害有所不同。

原始出处:

Jin Wang. Left Ventricular Deformation in Patients with Connective Tissue Disease: Evaluated by 3.0T Cardiac Magnetic Resonance Tissue Tracking. Sci Rep. 29 November 2019.

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    2019-12-30 wxl882001

    了解一下

    0

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